公开(公告)号：EP0958305A2

公开(公告)日：1999-11-24

申请号：EP97935511.0

申请日：1997-07-04

申请人： Novartis AG ,  CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED

发明人： LANE, David ,  BÖTTGER, Volker ,  BÖTTGER, Angelika ,  PICKSLEY, Stephen ,  HOCHKEPPEL, Heinz-Kurt ,  GARCIA-ECHEVERRIA, Carlos ,  CHENE, Patrick ,  FURET, Pascal

IPC分类号： G01N33 ,  A61K38 ,  A61K45 ,  A61P35 ,  C07K7 ,  C07K14 ,  C12N15 ,  C12Q1

CPC分类号： C07K7/04 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds, and uses of said compounds, e.g. in the therapeutic (including prophylactic) treatment of an animal or especially of the human body. The present further relates to methods of and compounds for inhibiting the growth of tumor cells which comprise the wild type p53 suppressor by interfering with the interaction between human p53 and human MDM2.