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公开(公告)号：EP3701947A1
公开(公告)日：2020-09-02
申请号：EP20159523.8
申请日：2009-05-14
发明人： ZAWEL, Leigh , DRANOFF, Glenn , DOUGAN, Michael , STRAUB, Christopher, S. , FIRESTONE, Brant, G.
IPC分类号： A61K31/437
摘要： The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics.
The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen.
Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.-
公开(公告)号：EP2296650B1
公开(公告)日：2020-05-06
申请号：EP09747530.5
申请日：2009-05-14
发明人： ZAWEL, Leigh , DRANOFF, Glenn , DOUGAN, Michael , STRAUB, Christopher, S. , FIRESTONE, Brant, G.
IPC分类号： A61P35/00 , A61K39/39 , A61K31/437
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公开(公告)号：EP2296650A1
公开(公告)日：2011-03-23
申请号：EP09747530.5
申请日：2009-05-14
发明人： ZAWEL, Leigh , DRANOFF, Glenn , DOUGAN, Michael , STRAUB, Christopher, S. , FIRESTONE, Brant, G.
IPC分类号： A61K31/437
摘要： The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
摘要翻译： 本发明涉及含有IAP抑制剂（包括Smac模拟物）的免疫佐剂。 本发明还提供含有IAP抑制剂和抗原的药物组合物和疫苗。 还提供了通过施用IAP抑制剂来增强免疫应答的方法，治疗或预防癌症的方法，治疗或预防感染的方法，治疗自身免疫疾病的方法，以及增强细胞因子或抗体产生的方法。
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4.发明公开CYCLIC AMIDE DERIVATIVES INHIBITORS OF THE INHIBITOR OF APOPTOSIS PROTEINS, THEIR PREPARATION, AND THEIR USE 审中-公开环酰胺凋亡蛋白抑制剂，其生产和使用衍生工具，抑制剂
公开(公告)号：EP1902065A2
公开(公告)日：2008-03-26
申请号：EP06760702.8
申请日：2006-06-06
申请人： Novartis AG , Novartis Pharma GmbH
发明人： CHEN, Zhuoliang , PALERMO, Mark, G. , SHARMA, Sushil, K. , SMITH, Troy , STRAUB, Christopher, S. , WANG, Run-Ming, D. , WANG, Yaping , ZAWEL, Leigh
CPC分类号： C07K5/0808 , C07D213/56 , C07D223/10 , C07D223/16 , C07D471/04 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0827 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula (I)
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