公开(公告)号：EP1501491A2

公开(公告)日：2005-02-02

申请号：EP03725069.3

申请日：2003-04-22

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： FUJIMOTO, Roger, Aki ,  URBAN, Laszlo,Novartis Institues for Biomedical ,  GONZALEZ, Isabel

IPC分类号： A61K31/196 ,  C07C229/42

CPC分类号： A61K31/196

摘要： The invention provides a method of treating cancer pain, e.g. bone cancer pain, in a subject in need of such treatment which comprises administering to the subject an effective amount of a COX-2 inhibitor; advantageously a compound of formula (I); wherein R, R1 R2, R3, R4, and R5 are as defined; a pharmaceutically acceptable salts thereof; or a pharmaceutically acceptable prodrug ester thereof.