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1.发明公开PHARMACEUTICAL COMPOSITION COMPRISING AN IMMUNOSUPPRESSANT FOR USE IN THE TREATMENT OF SKIN DISEASES 审中-公开药物组合物含中使用的免疫抑制剂的皮肤疾病的治疗
公开(公告)号：EP1613314A1
公开(公告)日：2006-01-11
申请号：EP04725324.0
申请日：2004-04-02
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
IPC分类号： A61K31/435 , A61K31/436 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/44
CPC分类号： A61K9/0014 , A61K31/435 , A61K31/436 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/44 , A61K2300/00
摘要： Synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and an emollient such as dimethicone, glycerol or isostearyl isostearate are provided, which are useful in particular in the treatment of dermatological or mucosal diseases such as dry skin or atopic or contact dermatitis.
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公开(公告)号：EP1296646A2
公开(公告)日：2003-04-02
申请号：EP01964968.0
申请日：2001-06-11
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： A61K9/00 , A61K31/135 , A61P31/10
CPC分类号： A61K31/135 , A61K9/2054
摘要： The present invention relates to sustained release pharmaceutical composition for oral administration comprising terbinafine.
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3.发明公开PHARMACEUTICAL COMPOSITION COMPRISING A MACROLIDE T-CELL IMMUNOMODULATOR AND ANTI-PHOTOAGING AGENT 审中-公开与大环内酯类T细胞的免疫调节剂和药物组合物中活性THAN光老化保护
公开(公告)号：EP1814546A1
公开(公告)日：2007-08-08
申请号：EP05801789.8
申请日：2005-11-14
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： HULTSCH, Thomas , PAUL, Carle , SEKKAT, Nabila , HIRSCH, Stefan
IPC分类号： A61K31/436 , A61K31/355 , A61K31/125 , A61K33/00 , A61P17/00 , A61P17/16
CPC分类号： A61K8/49 , A61K31/125 , A61K31/355 , A61K31/436 , A61K33/24 , A61Q19/08 , A61K2300/00
摘要： Compositions are provided comprising a macrolide T-cell immunomodulator or immunosuppressant agent, e.g. pimecrolimus, and at least one anti-photoaging agent such as a sunscreen, an anti-oxidant or a DNA-repair enzyme. They are useful in particular in the curative treatment or prevention of dermatological diseases and of conditions where it is desired to inhibit the skin aging effects of light radiation such as UV-A and UV-B light, e.g. development of skin cancer.
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4.发明公开COMBINATION OF A MACROLIDE T-CELL IMMUNOMODULATOR AND A CALCIFEROL FOR THE TREATMENT OF SKIN DISEASES OR OF INFLAMMATORY BOWEL DISEASE 审中-公开大环内酯类T细胞免疫调节剂的WITH A骨化醇FOR皮肤疾病或炎症性肠疾病的治疗组合
公开(公告)号：EP1613330A1
公开(公告)日：2006-01-11
申请号：EP04725344.8
申请日：2004-04-02
申请人： Novartis AG , Novartis Pharma GmbH
发明人： GRASSBERGER, Maximilian , HIRSCH, Stefan , MAYER, Friedrich, Karl , MEINGASSNER, Josef, Gottfried , PAUL, Carle , SEKKAT, Nabila
IPC分类号： A61K31/593 , A61K31/453 , A61P17/00 , A61P1/00
CPC分类号： A61K31/453 , A61K31/593 , A61K2300/00
摘要： Synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a calciferol such as calcipotriol or tacalcitol are provided, which are useful in particular in the treatment of dermatological diseases such as atopic dermatitis, acne and psoriasis, or of inflammatory bowel disease (IBD).
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5.发明公开SYNERGISTIC COMBINATIONS OF A MACROLIDE T-CELL MODULATOR OR IMMUNOSUPPRESSANT AND A RETINOID 审中-公开的协同组合33 EPICHLORO-33脱氧和维甲酸
公开(公告)号：EP1638543A2
公开(公告)日：2006-03-29
申请号：EP04725373.7
申请日：2004-04-02
申请人： Novartis AG
发明人： GRASSBERGER, Maximilian , HIRSCH, Stefan , MAYER, Friedrich, Karl , MEINGASSNER, Josef, Gottfried , PAUL, Carle , SEKKAT, Nabila , STÜTZ, Anton
IPC分类号： A61K31/05
CPC分类号： A61K31/05 , A61K31/07 , A61K31/436 , A61K2300/00
摘要： Additive or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33epichloro-33-desoxyascomycin and a retinoid, such as etretinate, isotretinoin or tazarotene, optionally with a further pharmaceutically active agent, especially an antibacterial, are provided, which are useful in particular in the treatment of dermatological diseases such as eczema, atopic dermatitis, acne, psoriasis, skin aging, sun damage, post-peel erythema and stretch marks.
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6.发明公开COMPOSITIONS COMPRISING MACROLIDE T-CELL IMMUNOMODULATORS OR IMMUNOSUPPRESSANTS IN COMBINATION WITH ANTIBACTERIALS 审中-公开具有抗菌剂的组合物大环内酯类T细胞或免疫调节IMMUNOSUPPRESSANTIEN合用
公开(公告)号：EP1613316A1
公开(公告)日：2006-01-11
申请号：EP04725330.7
申请日：2004-04-02
申请人： Novartis AG
发明人： GRASSBERGER, Maximilian , HILDEBRANDT, Johannes , HIRSCH, Stefan , PAUL, Carle , RYDER, Neil, Stewart , SEKKAT, Nabila , STÜTZ, Anton
IPC分类号： A61K31/436 , A61P31/04
CPC分类号： A61K31/635 , A61K31/436 , A61K2300/00
摘要： Highly compatible or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and an antibacterial such as sulfasalazin, ciprofloxacin, ofloxacin, erythromycin or gentamycin, optionally with a further pharmaceutically active agent, especially a retinoid, are provided, which are useful in particular in the treatment of diseases involving bacterial or suspected or anticipated bacterial infection, for immunomodulation or immunosuppression in conditions in which bacterial or suspected or anticipated bacterial colonisation of e.g. the skin plays a role, such as atopic, contact and seborrhoeic dermatitis, eczema, psoriasis, acne, rosacea, post-peel, skin burning, itching, or IBD, and in situations of bacterial resistance.
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