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1.发明授权9.ALPHA.-CHLORO-6.ALPHA.-FLUORO-17.ALPHA.-HYDROXY-16-METHYL-17-BETA-METHOXYCARBONYL-ANDROST-1,4-DIENES ESTERIFIED IN POSITION 17.ALPHA. BY A CYCLIC ACYL GROUP 有权9.ALPHA.氯6.ALPHA.氟17.ALPHA.羟基-16-甲基-17-β-甲氧羰基 - 雄甾-1,4-二烯IN THE 17.ALPHA。 逐环状酯基酯化
公开(公告)号：EP1299409B1
公开(公告)日：2005-04-06
申请号：EP01962783.5
申请日：2001-06-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： CUENOUD, Bernard , BEATTIE, David , KELLER, Thomas, Hugo , PILGRIM, Gaynor, Elizabeth , SANDHAM, David, Andrew , WATSON, Simon, James
CPC分类号： C07J41/0038 , C07J3/005 , C07J17/00 , C07J33/002 , C07J41/0094 , C07J43/003 , C07J71/0015
摘要： Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals.
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公开(公告)号：EP1622897A1
公开(公告)日：2006-02-08
申请号：EP04730527.1
申请日：2004-04-30
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BRUCE, Ian , CUENOUD, Bernard , KELLER, Thomas, Hugo , PILGRIM, Gaynor, Elizabeth , PRESS, Nicola , LE GRAND, Darren, Mark , RITCHIE, Cathy , VALADE, Barbara , HAYLER, Judy , BUDD, Emma
IPC分类号： C07D417/04 , C07D417/14 , A61K31/506 , A61K31/4436 , A61P29/00 , A61P9/10 , A61P3/04
CPC分类号： A61K31/5377 , A61K31/497 , A61K45/06 , C07D417/04 , C07D417/14
摘要： Compounds of formula (I) in free or salt form, wherein R1, R2, R3, and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
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3.发明公开9.ALPHA.-CHLORO-6.ALPHA.-FLUORO-17.ALPHA.-HYDROXY-16-METHYL-17-BETA-METHOXYCARBONYL-ANDROST-1,4-DIENES ESTERIFIED IN POSITION 17.ALPHA. BY A CYCLIC ACYL GROUP 有权9.ALPHA.氯6.ALPHA.氟17.ALPHA.羟基-16-甲基-17-β-甲氧羰基 - 雄甾-1,4-二烯IN THE 17.ALPHA。 逐环状酯基酯化
公开(公告)号：EP1299409A2
公开(公告)日：2003-04-09
申请号：EP01962783.5
申请日：2001-06-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： CUENOUD, Bernard , BEATTIE, David , KELLER, Thomas, Hugo , PILGRIM, Gaynor, Elizabeth , SANDHAM, David, Andrew , WATSON, Simon, James
CPC分类号： C07J41/0038 , C07J3/005 , C07J17/00 , C07J33/002 , C07J41/0094 , C07J43/003 , C07J71/0015
摘要： Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals.
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公开(公告)号：EP1622897B1
公开(公告)日：2009-10-14
申请号：EP04730527.1
申请日：2004-04-30
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BRUCE, Ian , CUENOUD, Bernard , KELLER, Thomas, Hugo , PILGRIM, Gaynor, Elizabeth , PRESS, Nicola , LE GRAND, Darren, Mark , RITCHIE, Cathy , VALADE, Barbara , HAYLER, Judy , BUDD, Emma
IPC分类号： C07D417/04 , C07D417/14 , A61K31/506 , A61K31/4436 , A61P29/00 , A61P9/10 , A61P3/04
CPC分类号： A61K31/5377 , A61K31/497 , A61K45/06 , C07D417/04 , C07D417/14
摘要： Compounds of formula (I) in free or salt form, wherein R1, R2, R3, and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
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