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公开(公告)号：EP1638558A2
公开(公告)日：2006-03-29
申请号：EP04725363.8
申请日：2004-04-02
申请人： Novartis AG , Novartis Pharma GmbH
发明人： GRASSBERGER, Maximilian , HIRSCH, Stefan , MAYER, Friedrich, Karl , SEKKAT, Nabila , STÜTZ, Anton
IPC分类号： A61K31/436 , A61K31/164 , A61P37/00 , A61P17/00
CPC分类号： A61K31/164 , A61K39/39 , A61K2300/00
摘要： Synergistic combination of a macrolide T -cell immunomodulator or immunosuppressant such as 33-epichloro-33desoxyascomycin and a ceramide such as ceramide 3, LPC-9S or linoleic acid are provided, which are useful in particular in the treatment of dermatological or mucosal diseases such as atopic or contact dermatitis or dry skin, asteatotic eczema or xerosis.
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公开(公告)号：EP1411921B2
公开(公告)日：2010-08-18
申请号：EP02754918.7
申请日：2002-07-19
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ALLES, Rainer , BECKER, Dieter , BONNY, Jean-Daniel , HIRSCH, Stefan , KALB, Oskar , KÖLLE, Ernst, Ulrich , MAYER, Friedrich, Karl , STÜTZ, Anton , WILLIAMS, Anthony
CPC分类号： A61K9/2846 , A61K9/2054 , A61K9/4808 , A61K31/135
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公开(公告)号：EP1411921A1
公开(公告)日：2004-04-28
申请号：EP02754918.7
申请日：2002-07-19
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ALLES, Rainer , BECKER, Dieter , BONNY, Jean-Daniel , HIRSCH, Stefan , KALB, Oskar , KÖLLE, Ernst, Ulrich , MAYER, Friedrich, Karl , STÜTZ, Anton , WILLIAMS, Anthony
CPC分类号： A61K9/2846 , A61K9/2054 , A61K9/4808 , A61K31/135
摘要： Pharmaceutical compositions for oral administration comprising terbinafine and a method for administering high dosages while minimizing effects associated with e.g. a high dosage load, e.g. coated tablets or multiparticulate formulations such as minitablets or pellets, e.g. in capsules.
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公开(公告)号：EP1411921B1
公开(公告)日：2007-12-19
申请号：EP02754918.7
申请日：2002-07-19
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ALLES, Rainer , BECKER, Dieter , BONNY, Jean-Daniel , HIRSCH, Stefan , KALB, Oskar , KÖLLE, Ernst, Ulrich , MAYER, Friedrich, Karl , STÜTZ, Anton , WILLIAMS, Anthony
CPC分类号： A61K9/2846 , A61K9/2054 , A61K9/4808 , A61K31/135
摘要： Pharmaceutical compositions for oral administration comprising terbinafine and a method for administering high dosages while minimizing effects associated with e.g. a high dosage load, e.g. coated tablets or multiparticulate formulations such as minitablets or pellets, e.g. in capsules.
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5.发明授权
公开(公告)号：EP1945217B1
公开(公告)日：2012-05-02
申请号：EP06791989.4
申请日：2006-09-12
申请人： Novartis AG
发明人： BILLICH, Andreas , STÜTZ, Anton
IPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/538 , A61K31/501 , A61K31/44 , A61K9/00 , A61K9/70 , A61K9/48 , A61K47/10 , A61K47/20 , A61P17/00 , A61P17/06 , A61P17/10
CPC分类号： A61K9/0014 , A61K9/4858 , A61K31/44 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/538 , A61K47/10 , A61K47/20
摘要： A composition comprising a VEGF receptor inhibitor and a penetration enhancer and uses thereof , for the treatment of dermatological diseases selected from psoriasis, atopic dermatitis and acne, are disclosed
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6.发明公开
公开(公告)号：EP1945217A2
公开(公告)日：2008-07-23
申请号：EP06791989.4
申请日：2006-09-12
申请人： Novartis AG
发明人： BILLICH, Andreas , STÜTZ, Anton
IPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/538 , A61K31/501 , A61K31/44 , A61K9/70 , A61P17/00 , A61P17/06 , A61P17/10
CPC分类号： A61K9/0014 , A61K9/4858 , A61K31/44 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/538 , A61K47/10 , A61K47/20
摘要： A composition comprising a VEGF receptor inhibitor and a penetration enhancer and uses thereof , for the treatment of dermatological diseases selected from psoriasis, atopic dermatitis and acne, are disclosed
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7.发明公开SYNERGISTIC COMBINATIONS OF A MACROLIDE T-CELL MODULATOR OR IMMUNOSUPPRESSANT AND A RETINOID 审中-公开的协同组合33 EPICHLORO-33脱氧和维甲酸
公开(公告)号：EP1638543A2
公开(公告)日：2006-03-29
申请号：EP04725373.7
申请日：2004-04-02
申请人： Novartis AG
发明人： GRASSBERGER, Maximilian , HIRSCH, Stefan , MAYER, Friedrich, Karl , MEINGASSNER, Josef, Gottfried , PAUL, Carle , SEKKAT, Nabila , STÜTZ, Anton
IPC分类号： A61K31/05
CPC分类号： A61K31/05 , A61K31/07 , A61K31/436 , A61K2300/00
摘要： Additive or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33epichloro-33-desoxyascomycin and a retinoid, such as etretinate, isotretinoin or tazarotene, optionally with a further pharmaceutically active agent, especially an antibacterial, are provided, which are useful in particular in the treatment of dermatological diseases such as eczema, atopic dermatitis, acne, psoriasis, skin aging, sun damage, post-peel erythema and stretch marks.
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8.发明公开COMPOSITIONS COMPRISING MACROLIDE T-CELL IMMUNOMODULATORS OR IMMUNOSUPPRESSANTS IN COMBINATION WITH ANTIBACTERIALS 审中-公开具有抗菌剂的组合物大环内酯类T细胞或免疫调节IMMUNOSUPPRESSANTIEN合用
公开(公告)号：EP1613316A1
公开(公告)日：2006-01-11
申请号：EP04725330.7
申请日：2004-04-02
申请人： Novartis AG
发明人： GRASSBERGER, Maximilian , HILDEBRANDT, Johannes , HIRSCH, Stefan , PAUL, Carle , RYDER, Neil, Stewart , SEKKAT, Nabila , STÜTZ, Anton
IPC分类号： A61K31/436 , A61P31/04
CPC分类号： A61K31/635 , A61K31/436 , A61K2300/00
摘要： Highly compatible or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and an antibacterial such as sulfasalazin, ciprofloxacin, ofloxacin, erythromycin or gentamycin, optionally with a further pharmaceutically active agent, especially a retinoid, are provided, which are useful in particular in the treatment of diseases involving bacterial or suspected or anticipated bacterial infection, for immunomodulation or immunosuppression in conditions in which bacterial or suspected or anticipated bacterial colonisation of e.g. the skin plays a role, such as atopic, contact and seborrhoeic dermatitis, eczema, psoriasis, acne, rosacea, post-peel, skin burning, itching, or IBD, and in situations of bacterial resistance.
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