公开(公告)号：EP1879882A1

公开(公告)日：2008-01-23

申请号：EP06742763.3

申请日：2006-05-02

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BAESCHLIN, Daniel, Kaspar ,  BREITENSTEIN, Werner ,  EHRHARDT, Claus ,  MAIBAUM, Juergen, Klaus ,  OSTERMANN, Nils ,  ZIMMERMANN, Juerg ,  RÜDISSER, Simon ,  VANGREVELINGHE. Eric ,  YOKOKAWA, Fumiaki

IPC分类号： C07D405/12 ,  C07D211/60 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D409/14 ,  A61K31/453 ,  A61K31/445 ,  A61K31/55 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/4535 ,  A61K31/4525 ,  A61P9/00

CPC分类号： C07D405/14 ,  C07D211/60 ,  C07D401/12 ,  C07D405/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： The invention relates to 3,5-piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5- piperidine compound, and/or a method of treatment comprising administering a 3,5- piperidine compound, a method for the manufacture of a 3,5-piperidine compound, and novel intermediates and partial steps for their synthesis. Especially, the 3,5-piperidine compounds have the formula I, wherein the symbols have the meanings described in the specification.