专利检索 ap:("Novartis AG" OR "Novartis Pharma GmbH" OR "THE UNIVERSITY OF NEWCASTLE UPON TYNE") AND inv:"ANDERSON, Judith, Rose" 第 1 页

1.

发明公开
COMBINATIONS COMPRISING EPOTHILONE DERIVATIVES AND ALKYLATING AGENTS 有权
标题翻译：的衍生物和埃博IMIDAZOTETRAZINONE复方制剂

公开(公告)号：EP1485090A2

公开(公告)日：2004-12-15

申请号：EP03720323.9

申请日：2003-03-07

申请人： Novartis AG , Novartis Pharma GmbH , THE UNIVERSITY OF NEWCASTLE UPON TYNE

发明人： ANDERSON, Judith, Rose , ROTHERMEL, John, David , MC SHEEHY, Paul, M.J. , BODDY, Alan

IPC分类号： A61K31/425

CPC分类号： A61K45/06 , A61K31/425 , A61K31/565 , A61K2300/00

摘要： The invention relates to a pharmaceutical combination which comprises (a) an alkylating agent and (b) an epothilone derivative of formula (I) wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond. Said combination can be useful for the treatment of a proliferative disease, especially a tumor disease.

2.

发明授权
COMBINATIONS COMPRISING AN EPOTHILONE DERIVATIVE AND AN IMIDAZOTETRAZINONE 有权
标题翻译：的衍生物和埃博IMIDAZOTETRAZINONE复方制剂

公开(公告)号：EP1485090B1

公开(公告)日：2007-10-10

申请号：EP03720323.9

申请日：2003-03-07

申请人： Novartis AG , Novartis Pharma GmbH , THE UNIVERSITY OF NEWCASTLE UPON TYNE

发明人： ANDERSON, Judith, Rose , ROTHERMEL, John, David , MC SHEEHY, Paul, M.J. , BODDY, Alan

IPC分类号： A61K31/425

CPC分类号： A61K45/06 , A61K31/425 , A61K31/565 , A61K2300/00

摘要： The invention relates to a pharmaceutical combination which comprises (a) an alkylating agent and (b) an epothilone derivative of formula (I) wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond. Said combination can be useful for the treatment of a proliferative disease, especially a tumor disease.