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1.发明授权USE OF A RAPAMYCIN DERIVATIVE IN VASCULOPATHIES AND XENOTRANSPLANTATION 无效使用一个RAPAMYCINDERIVATES治疗血管疾病及异种器官移植的治疗
公开(公告)号：EP0893996B1
公开(公告)日：2002-09-18
申请号：EP97915441.6
申请日：1997-03-26
IPC分类号： A61K31/435 , A61P9/00 , A61P43/00
CPC分类号： A61K31/436
摘要： Use of a rapamycin derivative of formula (I) as defined in the claims for preventing or treating vasculopathies and manifestations of xenotransplantation.
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公开(公告)号：EP0835263B9
公开(公告)日：2002-07-24
申请号：EP96924811.1
申请日：1996-06-28
发明人： ALBERT, Rainer , BAUER, Wilfried , BRUNS, Christian , CHANDRAMOULI, Nagarajan , LEWIS, Ian , WECKBECKER, Gisbert
IPC分类号： C07K14/655 , A61K38/31
CPC分类号： C07K14/6555 , A61K38/00 , A61K51/083 , A61K51/088
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公开(公告)号：EP0835263B1
公开(公告)日：2001-12-05
申请号：EP96924811.1
申请日：1996-06-28
发明人： ALBERT, Rainer , BAUER, Wilfried , BRUNS, Christian , CHANDRAMOULI, Nagarajan , LEWIS, Ian , WECKBECKER, Gisbert
IPC分类号： C07K14/655 , A61K38/31
CPC分类号： C07K14/6555 , A61K38/00 , A61K51/083 , A61K51/088
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公开(公告)号：EP0835263A2
公开(公告)日：1998-04-15
申请号：EP96924811.0
申请日：1996-06-28
发明人： ALBERT, Rainer , BAUER, Wilfried , BRUNS, Christian , CHANDRAMOULI, Nagarajan , LEWIS, Ian , WECKBECKER, Gisbert
IPC分类号： A61K38 , A61K51 , A61P3 , A61P5 , A61P9 , A61P27 , A61P29 , A61P35 , A61P37 , A61P43 , C07K5 , C07K14 , G06F13 , H04L9 , H04N7
CPC分类号： C07K14/6555 , A61K38/00 , A61K51/083 , A61K51/088
摘要： Somatostatin analogues comprising the amino acid sequence of the formula (I): -(D/L)Trp-Lys-X1-X2, wherein X1 is a substituted Thr, Ser, Tyr, Glu or Cys residue and X2 is an α-amino acid having an aromatic residue on the Cα side chain, or an amino acid unit selected from Dab, Dpr, Dpm, His (Bzl)HyPro, thienyl-Ala, cyclohexyl-Ala and t.-butyl-Ala, the residue Lys of said sequence corresponding to the residue Lys9 of the native somatostatin-14, in free form, in salt form or complexed with a detectable element have interesting pharmacological properties.
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5.发明授权COMBINATION COMPRISING N- 5- 4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO|-2-METHYLPHENYL -4-(3-PYRIDYL)-2PYRIMIDINE-AMINE AND A BIPHOSPHONATE 有权COMBINATION N- 5-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰胺基具有二膦酸酯-2-甲基-4-（3-吡啶基）-2PYRIMIDINE胺
公开(公告)号：EP1392313B1
公开(公告)日：2007-04-18
申请号：EP02743024.8
申请日：2002-05-15
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BRUNS, Christian , BUCHDUNGER, Elisabeth , O'REILLY, Terence , SILBERMAN, Sandra, Leta , WARTMANN, Markus , WECKBECKER, Gisbert
IPC分类号： A61K31/506 , A61P35/00 , A61P37/06 , A61K31/675
CPC分类号： A61K45/06 , A61K31/506
摘要： A method of treating a warm-blooded animal, especially a human, having a proliferative disease or acute or chronic transplant rejection comprising administering to the animal a combination which comprises (a) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and (b) a chemotherapeutic agent selected from antineoplastic agents, especially as defined herein, and agents effective in treating acute or chronic transplant rejection; a combination comprising (a) and (b) as defined above and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease.
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6.发明公开COMBINATION COMPRISING N- 5- 4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO]-2-METHYLPHENYL -4-(3-PYRIDYL)-2PYRIMIDINE-AMINE AND A CHEMOTHERAPEUTIC AGENT 有权COMBINATION N- 5-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰胺基具有二膦酸酯-2-甲基-4-（3-吡啶基）-2PYRIMIDINE胺
公开(公告)号：EP1392313A1
公开(公告)日：2004-03-03
申请号：EP02743024.8
申请日：2002-05-15
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BRUNS, Christian , BUCHDUNGER, Elisabeth , O'REILLY, Terence , SILBERMAN, Sandra, Leta , WARTMANN, Markus , WECKBECKER, Gisbert
IPC分类号： A61K31/506 , A61P35/00 , A61P37/06
CPC分类号： A61K45/06 , A61K31/506
摘要： A method of treating a warm-blooded animal, especially a human, having a proliferative disease or acute or chronic transplant rejection comprising administering to the animal a combination which comprises (a) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and (b) a chemotherapeutic agent selected from antineoplastic agents, especially as defined herein, and agents effective in treating acute or chronic transplant rejection; a combination comprising (a) and (b) as defined above and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease.
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公开(公告)号：EP1617868A1
公开(公告)日：2006-01-25
申请号：EP04727527.6
申请日：2004-04-15
申请人： Novartis AG , Novartis Pharma GmbH
发明人： FORSTNER, Michael , KLUMPP, Martin , LEDER, Lukas , NÜSSLEIN-HILDESHEIM, Barbara , RAULF, Friedrich , WECKBECKER, Gisbert
IPC分类号： A61K39/395 , A61K38/00 , A61K45/00 , A61P37/06
CPC分类号： A61K38/1709 , G01N2333/82 , G01N2500/02
摘要： The present invention provides a method for preventing or treating acute or chronic graft rejection in a recipient of cell, tissue or organ allo- or xenotransplant, inflammatory or autoimmune diseases or malignant proliferative disease, comprising the use of an inhibitor of Vav. Further provided are Vav inhibitors, uses, pharmaceutical compositions and therapeutic combinations comprising Vav inhibitors, and screening methods therefor.
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公开(公告)号：EP0896544B1
公开(公告)日：2003-02-26
申请号：EP97928175.5
申请日：1997-06-11
申请人： Novartis AG
发明人： WECKBECKER, Gisbert
CPC分类号： A61K38/31 , A61K2300/00
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9.发明公开USE OF RAPAMYCIN DERIVATIVES IN VASCULOPATHIES AND XENOTRANSPLANTATION 无效RAPAMYCINDERIVATEN的疾病和GEFA异种器官移植治疗中的应用
公开(公告)号：EP0893996A1
公开(公告)日：1999-02-03
申请号：EP97915441.0
申请日：1997-03-26
申请人： Novartis AG
CPC分类号： A61K31/436
摘要： Use of a rapamycin derivative of formula (I) as defined in the claims for preventing or treating vasculopathies and manifestations of xenotransplantation.
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公开(公告)号：EP1307486B1
公开(公告)日：2008-04-30
申请号：EP01969555.0
申请日：2001-07-30
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ALBERT, Rainer , BAUER, Wilfried , BODMER, David , BRUNS, Christian , FELNER, Ivo , HELLSTERN, Heribert , LEWIS, Ian , MEISENBACH, Mark , WECKBECKER, Gisbert , WIETFELD, Bernhard
IPC分类号： C07K14/655 , G01N33/74 , A61K51/08
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2-C2H4-NH-CO-O-)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
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