公开(公告)号：EP3212224A1

公开(公告)日：2017-09-06

申请号：EP15797871.9

申请日：2015-10-28

申请人： Novartis AG ,  The General Hospital Corporation

发明人： GEALL, Andrew ,  ALTER, Galit ,  SUSCOVICH, Todd

IPC分类号： A61K39/00 ,  C12N15/00 ,  C07K16/10 ,  A61K39/145 ,  C07K16/00

CPC分类号： C07K16/1018 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/515 ,  C07K16/00 ,  C07K16/10 ,  C07K2317/10 ,  C12N15/00 ,  C12N2760/16211 ,  C12N2770/32043 ,  C12N2770/36143 ,  C12N2830/20

摘要： The present invention relates to methods exogenous nucleic acid molecules, such as RNA, that encode an antibody or antigen-binding fragment of an antibody, and optionally encode a cellular modulation factor and/or a potentiation factor. The cellular modulation factor is a factor that results in increased expression of the antibody and/or antigen-binding fragment. The potentiation factor is a factor that provides desired antibody effector or other properties. The exogenous nucleic acid molecules can be DNA or RNA, as mRNA (including self-replication RNA and non-self-replicating RNA). The invention also relates method for administering the exogenous nucleic acid molecules to a subject to achieve production of the encoded antibody or antigen-binding fragment in the subject to provide, for example, prophylactic or therapeutic passive immunity.

摘要翻译： 本发明涉及编码抗体或抗体的抗原结合片段的外源性核酸分子如RNA的方法，并且任选编码细胞调节因子和/或增强因子。 细胞调节因子是导致抗体和/或抗原结合片段表达增加的因子。 增强因子是提供所需抗体效应物或其他性质的因子。 外源核酸分子可以是DNA或RNA，如mRNA（包括自我复制RNA和非自我复制RNA）。 本发明还涉及将外源性核酸分子施用于受试者以实现受试者中编码的抗体或抗原结合片段的产生以提供例如预防性或治疗性被动免疫的方法。