专利检索 ap:("Novartis AG" OR "The Trustees of The University of Pennsylvania" OR "Guedan Carrio, Sonia") AND inv:"JUNE, Carl. H" 第 1 页

1.

发明公开
SUBSET-OPTIMIZED CHIMERIC ANTIGEN RECEPTOR-CONTAINING T-CELLS 审中-公开

公开(公告)号：EP3660042A1

公开(公告)日：2020-06-03

申请号：EP19199959.8

申请日：2015-07-31

申请人： Novartis AG , The Trustees of The University of Pennsylvania , Guedan Carrio, Sonia

发明人： GUEDAN CARRIO, Sonia , JUNE, Carl. H , POSEY, Avery D. , SCHOLLER, John

IPC分类号： C07K14/705 , A61K35/17 , A61K31/436 , A61K39/00 , A61K39/395 , C07K14/725 , C07K16/28 , C12N5/0783

摘要： This disclosure provides, for instance subset-optimized CART cells and related methods. For instance, the disclosure describes methods and compositions of CD4 + and CD8 + T cells that express CARs containing specific combinations of intracellular signaling domains can be used to increase persistence and anti-tumor activity of the infused CAR-expressing T cells for treating a subject having a disease, e.g., a cancer.