公开(公告)号：EP1932856A3

公开(公告)日：2009-09-30

申请号：EP08000646.3

申请日：1994-09-13

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Tekamp-Olson, Patricia, A. ,  Mullenbach, Guy ,  Wernette-Hammond, Mary, Ellen

IPC分类号： C07K16/28 ,  A61K39/395

CPC分类号： C07K16/2866 ,  A61K38/00 ,  A61K2039/505

摘要： Inhibitors, including antibodies, of IL8 binding to its receptors, that interact with the amino-terminal extracellular domain of the IL8 receptor and which compete with IL8 for receptor-binding, are disclosed. The inhibitors are useful modulators of IL8 receptor-mediated biological activity.

公开(公告)号：EP1932856A2

公开(公告)日：2008-06-18

申请号：EP08000646.3

申请日：1994-09-13

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Tekamp-Olson, Patricia, A. ,  Mullenbach, Guy ,  Wernette-Hammond, Mary, Ellen

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A61K38/00 ,  A61K2039/505

摘要： Inhibitors, including antibodies, of IL8 binding to its receptors, that interact with the amino-terminal extracellular domain of the IL8 receptor and which compete with IL8 for receptor-binding, are disclosed. The inhibitors are useful modulators of IL8 receptor-mediated biological activity.

摘要翻译： 公开了与IL8受体结合的IL8的抑制剂，其与IL8受体的氨基末端胞外结构域相互作用并与IL8竞争受体结合。 抑制剂是IL8受体介导的生物活性的有用调节剂。