专利检索 ap:("Novartis Vaccines AND Diagnostics, Inc.") AND inv:"WU, Bin" 第 1 页

1.

发明授权
COMPOSITIONS AND METHODS FOR TREATING NEOPLASTIC DISEASE USING CHEMOTHERAPY AND RADIATION SENSITIZERS 有权
标题翻译：用于治疗肿瘤疾病的方法和组合物化疗和放射增敏剂的方式

公开(公告)号：EP1292289B1

公开(公告)日：2008-03-05

申请号：EP01948255.3

申请日：2001-05-30

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： WU, Bin , SEELEY, Todd, W. , WILLIAMS, Lewis, T.

IPC分类号： A61K31/00

CPC分类号： C12N15/1137 , A61K38/00 , C12N9/1205 , C12N2310/11 , C12Y207/01037

摘要： Inhibitors of KIAA0175 are provided that reduce the expression or biological activities of KIAA0175, p53 and/or p21 in a mammalian cell. KIAA0175 inhibitors include anti-sense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. KIAA0175 inhibitors find use in compositions and methods for decreasing KIAA0175, p53 and/or p21 gene expression as well as methods for increasing the chemo and/or radiosensitivity of mammalian cells, including tumor cells, methods for decreasing the side effects of cancer therapy and methods for treating neoplastic diseases.