公开(公告)号：EP2266628A3

公开(公告)日：2012-01-18

申请号：EP10179730.6

申请日：2004-05-12

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Zimmerman, Deborah Lee ,  Hansen, Rhonda ,  Winter, Jill ,  Reinhard, Christoph ,  Fang, Shuling

IPC分类号： A61K48/00 ,  C12Q1/68 ,  A61P35/00 ,  A61K31/663

CPC分类号： A61K31/663 ,  A61K31/7088 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides, inter alia, models of bone metastasis, methods for identifying agents that modulate skeletal related events and metastasis, methods for modulating skeletal related events and metastases, and methods for detecting skeletal related events and metastases. The methods and models generally comprise co-culturing cancer cells and host cells and comparing biological markers from such co-cultured cells to control cells.

公开(公告)号：EP2266628A2

公开(公告)日：2010-12-29

申请号：EP10179730.6

申请日：2004-05-12

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Zimmerman, Deborah Lee ,  Hansen, Rhonda ,  Winter, Jill ,  Reinhard, Christoph ,  Fang, Shuling

IPC分类号： A61K48/00 ,  C12Q1/68 ,  A61P35/00 ,  A61K31/663

CPC分类号： A61K31/663 ,  A61K31/7088 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides, inter alia, models of bone metastasis, methods for identifying agents that modulate skeletal related events and metastasis, methods for modulating skeletal related events and metastases, and methods for detecting skeletal related events and metastases. The methods and models generally comprise co-culturing cancer cells and host cells and comparing biological markers from such co-cultured cells to control cells.

摘要翻译： 本发明提供，尤其是骨转移的模型，用于确定药剂的方法做了调节骨相关事件和转移，用于调节骨相关事件和转移的方法，以及用于检测的骨相关事件和转移。 该方法和模型基因涨势包括共培养肿瘤细胞和宿主细胞并寻求共培养细胞来控制细胞比较生物学标记。