公开(公告)号：EP2266602A2

公开(公告)日：2010-12-29

申请号：EP10178110.2

申请日：2005-11-01

申请人： Novartis Vaccines and Diagnostics, Inc. ,  The Government of the U.S.A. as represented by The Secretary of the dept. of Health & Human Services

发明人： Barnett, Susan W. ,  Gomez-Roman, Victor Raul ,  Robert-Guroff, Marjorie ,  Srivastava, Indresh K.

IPC分类号： A61K39/21 ,  C07K14/16

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2760/16134

摘要： The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.

摘要翻译： 本发明涉及编码来自HIV亚型和/或不同亚型中的相同或不同菌株的免疫原性相同或类似的HIV多肽的方法，多肽和多核苷酸。 还描述了用于产生免疫应答的组合方法中多核苷酸和多肽的用途。 本文描述的组合方法诱导针对来自给定亚型中的多种菌株和针对不同亚型的多种HIV株的广泛和有效的免疫应答。 还公开了用于产生免疫应答的组合物的制剂和用于这种组合物的方法。

公开(公告)号：EP2266602A3

公开(公告)日：2011-08-10

申请号：EP10178110.2

申请日：2005-11-01

申请人： Novartis Vaccines and Diagnostics, Inc. ,  The Government of the U.S.A. as represented by The Secretary of the dept. of Health & Human Services

发明人： Barnett, Susan W. ,  Gomez-Roman, Victor Raul ,  Robert-Guroff, Marjorie ,  Srivastava, Indresh K.

IPC分类号： A61K39/21 ,  C07K14/16

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2760/16134

摘要： The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.