公开(公告)号：EP1301516B1

公开(公告)日：2006-03-22

申请号：EP01949271.9

申请日：2001-06-28

申请人： NOVO NORDISK A/S ,  Ontogen Corporation

发明人： ANDERSEN, Henrik, Sune ,  HANSEN, Thomas, Kruse ,  LAU, Jesper ,  MOLLER, Niels Peter, Hundahl ,  OLSEN, Ole, Hvilsted ,  AXE, Frank, Urban ,  BAKIR, Farid ,  GE, Yu ,  HOLSWORTH, Daniel, Dale ,  JUDGE, Luke, Milburn ,  NEWMAN, Michael, James ,  UYEDA, Roy, Teruyuki ,  SHAPIRA, Barry, Zvi

IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61P3/00 ,  A61P5/48 ,  A61P37/00 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D495/04 ,  A61K31/4365

摘要： The present invention provides novel thienopyridines, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP; wherein X, R1, R2, R3 and R4 are defined more fully in the description. The compounds are useful in the treatment of type diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.

公开(公告)号：EP1214324A1

公开(公告)日：2002-06-19

申请号：EP00958276.8

申请日：2000-09-11

申请人： NOVO NORDISK A/S ,  Ontogen Corporation

发明人： ANDERSEN, Henrik, Sune ,  HANSEN, Thomas, Kruse ,  LAU, Jesper ,  M LLER, Niels, Peter, Hundahl ,  OLSEN, Ole, Hvilsted ,  AXE, Frank, Urban ,  GE, Yu ,  HOLSWORTH, Daniel, Dale ,  JONES, Todd, Kevin ,  JUDGE, Luke, Milburn ,  RIPKA, Wiliam, Charles ,  SHAPIRA, Barry, Zvi ,  UYEDA, Roy, Teruyuki

IPC分类号： C07D495/04 ,  C07D491/04 ,  A61K31/4365 ,  A61K31/4355 ,  A61P3/00 ,  A61P5/00 ,  A61P7/00 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D495/04 ,  A61K31/4365 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula (1) are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP, wherein n, m, X, R1, R2, R3, R4, R5, R6, and R7 are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.

摘要翻译： 本发明提供了新的化合物，新组合物，它们的使用方法和它们的制造方法，其中这些式（1）化合物是蛋白质酪氨酸磷酸酶（PTPase's）的药理学上有用的抑制剂，包括PTP1B，T细胞PTP， 在说明书中更全面地定义了m，X，R1，R2，R3，R4，R5，R6和R7。 这些化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖和其他疾病。

公开(公告)号：EP0910579A1

公开(公告)日：1999-04-28

申请号：EP97919296.0

申请日：1997-04-18

申请人： NOVO NORDISK A/S

发明人： RICHTER, Stefan, Lutz ,  MADSEN, Kjeld ,  THOEGERSEN, Henning ,  JOHANSEN, Nils, Langeland ,  HANSEN, Annette ,  OLSEN, Ole, Hvilsted ,  ANDERSEN, Peter, Hoengaard

IPC分类号： A61K38 ,  A61K31 ,  A61P5 ,  A61P15 ,  A61P19 ,  A61P25 ,  A61P37 ,  C07K7 ,  C07K14

CPC分类号： C07K14/60 ,  A61K38/00

摘要： The present invention relates to truncated GHRs of general formula (I): K-(M)x-A-B-(C)w-D-E-(F)z-G-(N)y-L which have the ability to stimulate release of endogenous growth hormone.

公开(公告)号：EP1301516A1

公开(公告)日：2003-04-16

申请号：EP01949271.9

申请日：2001-06-28

申请人： NOVO NORDISK A/S ,  Ontogen Corporation

发明人： ANDERSEN, Henrik, Sune ,  HANSEN, Thomas, Kruse ,  LAU, Jesper ,  MOLLER, Niels Peter, Hundahl ,  OLSEN, Ole, Hvilsted ,  AXE, Frank, Urban ,  BAKIR, Farid ,  GE, Yu ,  HOLSWORTH, Daniel, Dale ,  JUDGE, Luke, Milburn ,  NEWMAN, Michael, James ,  UYEDA, Roy, Teruyuki ,  SHAPIRA, Barry, Zvi

IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61P3/00 ,  A61P5/48 ,  A61P37/00 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D495/04 ,  A61K31/4365

摘要： The present invention provides novel thienopyridines, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP; wherein X, R1, R2, R3 and R4 are defined more fully in the description. The compounds are useful in the treatment of type diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.

公开(公告)号：EP1214325A1

公开(公告)日：2002-06-19

申请号：EP00958277.6

申请日：2000-09-11

申请人： NOVO NORDISK A/S ,  Ontogen Corporation

发明人： ANDERSEN, Henrik, Sune ,  HANSEN, Thomas, Kruse ,  LAU, Jesper ,  M LLER, Niels, Peter, Hundahl ,  OLSEN, Ole, Hvilsted ,  AXE, Frank, Urban ,  GE, Yu ,  HOLSWORTH, Daniel, Dale ,  JONES, Todd, Kevin ,  JUDGE, Luke, Milburn ,  RIPKA, Wiliam, Charles ,  SHAPIRA, Barry, Zvi ,  UYEDA, Roy, Teruyuki

IPC分类号： C07D495/04 ,  C07D513/04 ,  C07D493/04 ,  A61K31/381 ,  A61K31/395 ,  A61P3/00 ,  A61P5/00 ,  A61P7/00 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D495/04

摘要： The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula (1) are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like, wherein n, m, X, Y, R1, R2, R3, R4, R5 and R6 are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.

公开(公告)号：EP0563169B1

公开(公告)日：1997-10-29

申请号：EP92901590.7

申请日：1991-12-19

申请人： NOVO NORDISK A/S

发明人： BRANNER, Sven ,  HASTRUP, Sven ,  OLSEN, Ole, Hvilsted ,  ERIKSEN, Nina ,  LINDEGAARD, Poul ,  CASTELEIJN, Eric ,  MAARTEN, Robert, Egmond ,  HAVERKAMP, Johan ,  MUSTERS, Wouter ,  DE VLIEG, Jakob

IPC分类号： C12N9/56 ,  C12N15/57 ,  C11D3/386

CPC分类号： C11D3/386 ,  C12N9/54

摘要： This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions containing them.

公开(公告)号：EP0621869B1

公开(公告)日：1997-04-23

申请号：EP93902103.6

申请日：1993-01-07

申请人： NOVO NORDISK A/S

发明人： BJOERN, SOEREN, Erik ,  NORRIS, Kjeld ,  NORRIS, Fanny ,  PETERSEN, Lars, Christian ,  OLSEN, Ole, Hvilsted

IPC分类号： C07K14/81 ,  C12N15/15 ,  A61K38/55

CPC分类号： C07K14/8114 ,  A61K38/00

摘要： A variant of the C-terminal Kunitz-type protease inhibitor domain of the α3 chain of human type VI collagen, the variant comprising the amino acid sequence (I) wherein X1 represents H or 1-5 naturally occurring amino acid residues except Cys, X2-X14 each independently represents a naturally occurring amino acid residue, and X15 represents OH or 1-5 naturally occurring amino acid residues except Cys, with the proviso that at least one of the amino acid residues X1-X15 is different from the corresponding amino acid residue of the native sequence.

公开(公告)号：EP0563169A1

公开(公告)日：1993-10-06

申请号：EP92901590.0

申请日：1991-12-19

申请人： NOVO NORDISK A/S

发明人： BRANNER, Sven ,  HASTRUP, Sven ,  OLSEN, Ole, Hvilsted ,  ERIKSEN, Nina ,  LINDEGAARD, Poul ,  CASTELEIJN, Eric ,  MAARTEN, Robert, Egmond ,  HAVERKAMP, Johan ,  MUSTERS, Wouter ,  DE VLIEG, Jakob

IPC分类号： C11D3 ,  C12N9 ,  C12N15 ,  C12R1

CPC分类号： C11D3/386 ,  C12N9/54

摘要： On décrit des enzymes, des techniques d'ADNr adaptés par example à la production de celles-ci, des gènes ayant subi une mutation, des vecteurs et des micro-organismes mutants et transformés utiles à la production de ceux-ci, et leurs applications, par exemple, aux détergents enzymatiques et aux compositions de lavage les contenant.

公开(公告)号：EP1319067A2

公开(公告)日：2003-06-18

申请号：EP01967077.7

申请日：2001-09-13

申请人： NOVO NORDISK A/S

发明人： PERSSON, Egon ,  OLSEN, Ole, Hvilsted

IPC分类号： C12N9/64 ,  A61K38/48 ,  C07K14/745

CPC分类号： C12N9/647 ,  A61K38/4846 ,  C12N9/6437 ,  C12Y304/21021

摘要： The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as nucleic acid constructs encoding such variants, vectors and host cells comprising and expressing the nucleic acid, pharmaceutical compositions, uses and methods of treatment. The variant comprises a substitution in at least one amino acid position, selected from the group consisting of positions Lys 157, Lys 337, Asp 334, Ser 336, Val 158, Glu 296 and Met 298.

公开(公告)号：EP1214060A2

公开(公告)日：2002-06-19

申请号：EP00963340.5

申请日：2000-09-11

申请人： NOVO NORDISK A/S ,  Ontogen Corporation

发明人： ANDERSEN, Henrik, Sune ,  HANSEN, Thomas, Kruse ,  Iverson, Lars Fogh ,  LAU, Jesper ,  M LLER, Niels, Peter, Hundahl ,  OLSEN, Ole, Hvilsted ,  AXE, Frank, Urban ,  GE, Yu ,  HOLSWORTH, Daniel, Dale ,  JONES, Todd, Kevin ,  JUDGE, Luke, Milburn ,  RIPKA, William, Charles ,  SHAPIRA, Barry, Zvi ,  UYEDA, Roy Teruyuki

IPC分类号： A61K31/00 ,  A61K31/435 ,  A61K31/381 ,  A61K31/38

CPC分类号： C07D495/04 ,  A61K31/00 ,  A61K31/38 ,  A61K31/381 ,  A61K31/435 ,  A61K45/06

摘要： The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPν, PTPδ, PTPσ, PTPz, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP by exposing said Ptpase member by administration to a host or otherwise to at least one compound with certain structural, physical and spatial characteristics that allow for the interaction of said compound with specific residues of the active site of PTP1B and/or TC-PTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes, as well as in the isolation of PTPases and in elucidation or further elucidation of their biological function.