公开(公告)号：EP1478399B1

公开(公告)日：2012-03-21

申请号：EP03704652.1

申请日：2003-02-19

申请人： Nycomed GmbH

发明人： DIETRICH, Rango ,  EISTETTER, Klaus ,  NEY, Hartmut

IPC分类号： A61K45/06 ,  A61K9/20 ,  A61K31/166 ,  A61K31/44 ,  A61P11/06

CPC分类号： A61K9/0002 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/166 ,  A61K31/44

摘要： Dosage forms for oral administration of a PDE 4 inhibitor whose solubility is slight are described. They contain PVP as binder.

公开(公告)号：EP1868671A1

公开(公告)日：2007-12-26

申请号：EP06724114.1

申请日：2006-04-07

申请人： Nycomed GmbH

发明人： EISTETTER, Klaus ,  WURST, Wilhelm ,  POHLMANN, Gerhard ,  WINDT, Horst ,  NOLTE, Oliver ,  KOCH, Wolfgang

IPC分类号： A61M11/06 ,  A61M15/00 ,  B05B11/06 ,  B05B7/14 ,  A61M16/20

CPC分类号： A61M11/06 ,  A61M11/065 ,  A61M15/0065 ,  A61M15/0086 ,  A61M16/14 ,  A61M16/202 ,  A61M2016/0027 ,  A61M2202/064 ,  B05B7/1404

摘要： The invention relates to a device (1) for dosing and dry nebulization of nebulizable material (12) chosen from the group comprising anti- infective agents and immunomodulators, comprising a nebulization channel (3), which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve (16) for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir (10) open only towards the nebulization channel, which contains the nebulizable material (12), is connected to the nebulizaton channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation (22) takes place in the nebulization channel and in the reservoir. The invention also relates to a method for dosing and dry nebulization of such a nebulizable material by means of such a device.

摘要翻译： 本发明涉及一种用于对包含雾化通道（3）的可雾化材料（12）进行定量给药和干雾化的设备（1），所述雾化材料（12）选自包含抗感染剂和免疫调节剂的组，所述雾化通道具有第一附接件和第二附件 以及经由阀（16）连接到第一附接件的压缩载气源，用于将载气压力脉冲发送到雾化通道中。 该装置的特征在于，在第一附接件和第二附接件之间并且在雾化通道上方，仅朝向包含可雾化材料（12）的雾化通道打开的储存器（10）连接至雾化通道， 它相对于环境是气密的，并且当阀门关闭时，在雾化通道和储存器中发生压力补偿（22）。 本发明还涉及一种借助于这种装置对这种可雾化材料进行定量给药和干燥雾化的方法。

公开(公告)号：EP1611150B1

公开(公告)日：2012-02-22

申请号：EP04723609.6

申请日：2004-03-26

申请人： Nycomed GmbH

发明人： SCHMIDT, Beate ,  EISTETTER, Klaus ,  KAUPP, Stefan ,  STURM, Ernst

IPC分类号： C07J71/00 ,  B01F1/00

CPC分类号： C07J71/00

摘要： The invention relates to a novel process for preparing crystalline ciclesonide with an advantageous particle size and to the use for producing pharmaceutical preparations, in particular for topical use. The crystalline ciclesonide obtained by the novel process has advantageous aerodynamic properties, and can be further processed to inhalable or nasally administered pharmaceutical preparations without further mechanical micronization.

公开(公告)号：EP1670481B1

公开(公告)日：2010-08-04

申请号：EP04766789.4

申请日：2004-09-15

申请人： Nycomed GmbH

发明人： ABEL, Florian ,  BRUECK-SCHEFFLER, Antje ,  DIETZEL, Klaus ,  EISTETTER, Klaus ,  NAVE, Ruediger ,  POSTIUS, Stefan ,  VON RICHTER, Oliver

IPC分类号： A61K31/58 ,  A61P1/00

CPC分类号： A61K31/58

摘要： The invention relates to the novel use of ciclesonide in the treatment of inflammatory bowel disease.