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公开(公告)号：EP0232179B1
公开(公告)日：1992-07-22
申请号：EP87301040.9
申请日：1987-02-05
发明人： Linsley, Peter S. , Ochs, Vincent W. , Horn, Diane , Brown, Joseph P. , Ring, David B. , Frankel, Arthur E.
IPC分类号： G01N33/574 , G01N33/577
CPC分类号： G01N33/57415 , Y10S436/813
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公开(公告)号：EP0268279A3
公开(公告)日：1991-07-03
申请号：EP87116997.5
申请日：1987-11-17
发明人： Linsley, Peter S. , Horn, Diane , Brown, Joseph P.
IPC分类号： C12N5/12 , C07K16/28 , C07K16/30 , C12P21/08 , G01N33/577 , G01N33/68 , A61K39/395 , G01N33/574
CPC分类号： C07K16/3023 , A61K38/00 , C07K16/3015
摘要： Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sources are demonstrated to be distinct, using these new antibodies. The antibodies may be useful alone or in combination, in the diagnosis and treatment of cancer including malignancies of the breast and lung.
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公开(公告)号：EP0232179A2
公开(公告)日：1987-08-12
申请号：EP87301040.9
申请日：1987-02-05
发明人： Linsley, Peter S. , Ochs, Vincent W. , Horn, Diane , Brown, Joseph P. , Ring, David B. , Frankel, Arthur E.
IPC分类号： G01N33/574 , G01N33/577
CPC分类号： G01N33/57415 , Y10S436/813
摘要： Methods are disclosed for detecting, staging and monitoring breast cancer. The methods involve determining the amount of certain antigens, designated W1 and W9, in serum via quantitative immunoassays using anti-W1 or anti-W9 monoclonal antibodies. The amount detected is compared with amounts of the antigen found in normal sera, sera from breast cancer patients of predetermined stage, or other samples of the patient's own serum, depending upon the purpose of the assay.
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公开(公告)号：EP0268279B1
公开(公告)日：1995-11-08
申请号：EP87116997.5
申请日：1987-11-17
发明人： Linsley, Peter S. , Horn, Diane , Brown, Joseph P.
IPC分类号： C12N5/12 , C07K16/28 , C07K16/30 , C12P21/08 , G01N33/577 , G01N33/68 , A61K39/395 , G01N33/574
CPC分类号： C07K16/3023 , A61K38/00 , C07K16/3015
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公开(公告)号：EP0232179A3
公开(公告)日：1989-09-06
申请号：EP87301040.9
申请日：1987-02-05
发明人： Linsley, Peter S. , Ochs, Vincent W. , Horn, Diane , Brown, Joseph P. , Ring, David B. , Frankel, Arthur E.
IPC分类号： G01N33/574 , G01N33/577
CPC分类号： G01N33/57415 , Y10S436/813
摘要： Methods are disclosed for detecting, staging and monitoring breast cancer. The methods involve determining the amount of certain antigens, designated W1 and W9, in serum via quantitative immunoassays using anti-W1 or anti-W9 monoclonal antibodies. The amount detected is compared with amounts of the antigen found in normal sera, sera from breast cancer patients of predetermined stage, or other samples of the patient's own serum, depending upon the purpose of the assay.
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6.发明公开Hybridomas producing monoclonal antibodies to new mucin epitopes 失效MonoklonaleAntikörpergegen neue Epitopen des Mucins produzierende Hybridome。
公开(公告)号：EP0268279A2
公开(公告)日：1988-05-25
申请号：EP87116997.5
申请日：1987-11-17
发明人： Linsley, Peter S. , Horn, Diane , Brown, Joseph P.
IPC分类号： C12N5/12 , C07K16/28 , C07K16/30 , C12P21/08 , G01N33/577 , G01N33/68 , A61K39/395 , G01N33/574
CPC分类号： C07K16/3023 , A61K38/00 , C07K16/3015
摘要： Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sources are demonstrated to be distinct, using these new antibodies. The antibodies may be useful alone or in combination, in the diagnosis and treatment of cancer including malignancies of the breast and lung.
摘要翻译： 使用粘蛋白（包括来自肿瘤来源的纯化的粘蛋白）产生产生与来自正常和肿瘤来源的纯化的粘蛋白抗原反应的单克隆抗体的新型杂交瘤细胞系。 使用这些新抗体证明来自正常和肿瘤来源的粘蛋白抗原的表位是不同的。 抗体可以单独使用或组合用于诊断和治疗包括乳腺和肺的恶性肿瘤的癌症。
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