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1.发明公开Normal human growth regulatory receptor for TGF beta 失效正常人TGF-Rezeptor，das Wachstum bei Menschen regelnd。
公开(公告)号：EP0369861A2
公开(公告)日：1990-05-23
申请号：EP89403084.0
申请日：1989-11-08
CPC分类号： C07K14/71
摘要： Type III TGF-β receptor is identified in and purified from normal human embryonic palatal mesenchyme (HEPM) cells and the purified product characterized structurally and functionally. HEPM cells were found to express high levels of the type III TGF-β receptor and were found to significantly down-regulate two classes of TGF-β receptor binding site. Purification of the type III TGF-β receptor from solubilized HEPM cell membranes by affinity chromatography yielded a biologically active protein of about 205 kd which specifically binds both the recombinant and natural forms of TGF-β1 and TGF-β2, with affinity dissociation constants in the picomolar range.
摘要翻译： III型TGF-β受体在正常人胚胎腭裂间质（HEPM）细胞中鉴定并纯化，纯化的产物在结构和功能上表征。 发现HEPM细胞表达高水平的III型TGF-β受体，并被发现显着下调两类TGF-β受体结合位点。 通过亲和层析从溶解的HEPM细胞膜中纯化III型TGF-β受体，得到约205kd的生物活性蛋白，其特异性结合重组和天然形式的TGF-β1和TGF-β2，具有亲和解离常数 在皮摩摩范围内。
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公开(公告)号：EP0369861A3
公开(公告)日：1991-09-11
申请号：EP89403084.0
申请日：1989-11-08
CPC分类号： C07K14/71
摘要： Type III TGF-β receptor is identified in and purified from normal human embryonic palatal mesenchyme (HEPM) cells and the purified product characterized structurally and functionally. HEPM cells were found to express high levels of the type III TGF-β receptor and were found to significantly down-regulate two classes of TGF-β receptor binding site. Purification of the type III TGF-β receptor from solubilized HEPM cell membranes by affinity chromatography yielded a biologically active protein of about 205 kd which specifically binds both the recombinant and natural forms of TGF-β1 and TGF-β2, with affinity dissociation constants in the picomolar range.
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