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公开(公告)号：EP0248642B1
公开(公告)日：1992-10-21
申请号：EP87304883.9
申请日：1987-06-03
CPC分类号： C07K14/4718 , A61K38/00 , C12P1/04 , C12R1/91
摘要： Methods and compositions are provided for production of novel polypeptides having antineoplastic activity. Polypeptides are obtained by lymphokine activation of killer lymphocytes, solubilizing peptides from the cells with acidic ethanolic extraction and purification using chromatography. The resulting peptides may be prepared by other techniques, such as synthesis or expression in nonmammalian or mammalian host cells. The peptides find use in inhibition of neoplastic cell proliferation.
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公开(公告)号：EP0248642A3
公开(公告)日：1989-11-02
申请号：EP87304883.9
申请日：1987-06-03
CPC分类号： C07K14/4718 , A61K38/00 , C12P1/04 , C12R1/91
摘要： Methods and compositions are provided for production of novel polypeptides having antineoplastic activity. Polypeptides are obtained by lymphokine activation of killer lymphocytes, solubilizing peptides from the cells with acidic ethanolic extraction and purification using chromatography. The resulting peptides may be prepared by other techniques, such as synthesis or expression in nonmammalian or mammalian host cells. The peptides find use in inhibition of neoplastic cell proliferation.
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公开(公告)号：EP0248642A2
公开(公告)日：1987-12-09
申请号：EP87304883.9
申请日：1987-06-03
CPC分类号： C07K14/4718 , A61K38/00 , C12P1/04 , C12R1/91
摘要： Methods and compositions are provided for production of novel polypeptides having antineoplastic activity. Polypeptides are obtained by lymphokine activation of killer lymphocytes, solubilizing peptides from the cells with acidic ethanolic extraction and purification using chromatography. The resulting peptides may be prepared by other techniques, such as synthesis or expression in nonmammalian or mammalian host cells. The peptides find use in inhibition of neoplastic cell proliferation.
摘要翻译： 提供了用于生产具有抗肿瘤活性的新型多肽的方法和组合物。 多肽通过淋巴因子激活杀伤淋巴细胞获得，通过酸性乙醇萃取从细胞中增溶肽，并使用色谱法纯化。 所得肽可以通过其它技术制备，例如在非哺乳动物宿主细胞中的合成或表达。 肽可用于抑制肿瘤细胞增殖。
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