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公开(公告)号：EP0306995B1
公开(公告)日：1997-04-02
申请号：EP88114834.0
申请日：1988-09-09
发明人： Hellstrom, Ingegerd , Hellstrom, Karl Frik , Kahn, Maria S. , Beaton, Donna Francine , Lee, Victor K.
IPC分类号： C07K16/42 , A61K39/395 , G01N33/574
CPC分类号： C07K16/3023 , A61K38/00 , A61K39/00 , C07K16/28 , C07K16/2809 , C07K16/30 , C07K16/4266 , C07K2317/732 , C07K2317/734 , G01N33/57423 , G01N33/5743 , G01N33/57476 , G01N33/57488
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公开(公告)号：EP0759442A1
公开(公告)日：1997-02-26
申请号：EP96111623.3
申请日：1988-09-09
发明人： Hellstrom, Ingegard , Hellstrom, Karl Frik , Kahn, Maria S. , Beaton, Donna Francine , Lee, Victor K.
IPC分类号： C07K16/42 , G01N33/577
CPC分类号： C07K16/3023 , A61K38/00 , A61K39/00 , C07K16/28 , C07K16/2809 , C07K16/30 , C07K16/4266 , C07K2317/732 , C07K2317/734 , G01N33/57423 , G01N33/5743 , G01N33/57476 , G01N33/57488
摘要： The present invention relates to methods which utilize anti-idiotypic antibodies, or fragments thereof, for tumor immunotherapy or immunoprophylaxis. Monoclonal anti-idiotypic antibodies which recognize an idiotype present on a second antibody or on a T lymphocyte or on an immune suppressor factor which is directed against a defined tumor antigen, can be used for immunization against a tumor, for immune anti-tumor activation or inhibition of suppression, or for in vitro activation of lymphocytes to be used in adoptive immunotherapy. The anti-idiotypic antibodies, or fragments thereof, can also be used to monitor anti-antibody induction in patients undergoing passive immunization to a tumor antigen by administration of anti-tumor antibody In another embodiment, administration of T lymphocytes which express an idiotype directed against a defined tumor antigen can be used to transfer delayed-type hypersensitivity to the tumor. In another method of the invention, the induction of anti-idiotypic antibodies in vivo by administration of anti-tumor antibody or immune cells or factors exhibiting an anti-tumor idiotype can be therapeutically valuable.
摘要翻译： 本发明涉及利用抗独特型抗体或其片段用于肿瘤免疫治疗或免疫预防的方法。 识别存在于第二抗体或T淋巴细胞上的独特型单克隆抗单克隆抗体或针对定义的肿瘤抗原的免疫抑制因子的单克隆抗独特型抗体可用于针对肿瘤的免疫，免疫抗肿瘤活化或 抑制或抑制用于过继免疫治疗的淋巴细胞的体外活化。 抗独特型抗体或其片段也可以用于监测通过施用抗肿瘤抗体进行对肿瘤抗原的被动免疫的患者的抗 - 抗体诱导。 在另一个实施方案中，可以使用表达针对定义的肿瘤抗原的独特型的T淋巴细胞的施用来将延迟型超敏反应转移至肿瘤。 在本发明的另一种方法中，通过施用抗肿瘤抗体或免疫细胞或显示抗肿瘤独特型的因子在体内诱导抗独特型抗体可以具有治疗价值。
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公开(公告)号：EP0306995A3
公开(公告)日：1990-03-07
申请号：EP88114834.0
申请日：1988-09-09
发明人： Hellstrom, Ingegerd , Hellstrom, Karl Frik , Kahn, Maria S. , Beaton, Donna Francine , Lee, Victor K.
IPC分类号： C07K16/42 , A61K39/395 , G01N33/574
CPC分类号： C07K16/3023 , A61K38/00 , A61K39/00 , C07K16/28 , C07K16/2809 , C07K16/30 , C07K16/4266 , C07K2317/732 , C07K2317/734 , G01N33/57423 , G01N33/5743 , G01N33/57476 , G01N33/57488
摘要： The present invention relates to methods which utilize anti-idiotypic antibodies, or fragments thereof, for tumor immunotherapy or immunoprophylaxis. Monoclonal anti-idiotypic antibodies which recognize an idiotype present on a second antibody or on a T lymphocyte or on an immune suppressor factor which is directed against a defined tumor antigen, can be used for immunization against a tumor, for immune anti-tumor activation or inhibition of suppression, or for in vitro activation of lymphocytes to be used in adoptive immunotherapy. The anti-idiotypic antibodies, or fragments thereof, can also be used to monitor anti-antibody induction in patients undergoing passive immunization to a tumor antigen by administration of anti-tumor antibody. In another embodiment, administration of T lymphocytes which express an idiotype directed against a defined tumor antigen can be used to transfer delayed-type hypersensitivity to the tumor. In another method of the invention, the induction of anti-idiotypic antibodies in vivo by administration of anti-tumor antibody or immune cells or factors exhibiting an anti-tumor idiotype can be therapeutically valuable.
摘要翻译： 本发明涉及利用抗独特型抗体或其片段用于肿瘤免疫治疗或免疫预防的方法。 识别存在于第二抗体或T淋巴细胞上的独特型单克隆抗单克隆抗体或针对定义的肿瘤抗原的免疫抑制因子的单克隆抗独特型抗体可用于针对肿瘤的免疫，免疫抗肿瘤活化或 抑制或抑制用于过继免疫治疗的淋巴细胞的体外活化。 抗独特型抗体或其片段也可以用于监测通过施用抗肿瘤抗体进行对肿瘤抗原的被动免疫的患者的抗 - 抗体诱导。 在另一个实施方案中，可以使用表达针对定义的肿瘤抗原的独特型的T淋巴细胞的施用来将延迟型超敏反应转移至肿瘤。 在本发明的另一种方法中，通过施用抗肿瘤抗体或免疫细胞或显示抗肿瘤独特型的因子在体内诱导抗独特型抗体可以具有治疗价值。
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公开(公告)号：EP0306995A2
公开(公告)日：1989-03-15
申请号：EP88114834.0
申请日：1988-09-09
发明人： Hellstrom, Ingegerd , Hellstrom, Karl Frik , Kahn, Maria S. , Beaton, Donna Francine , Lee, Victor K.
IPC分类号： C07K16/42 , A61K39/395 , G01N33/574
CPC分类号： C07K16/3023 , A61K38/00 , A61K39/00 , C07K16/28 , C07K16/2809 , C07K16/30 , C07K16/4266 , C07K2317/732 , C07K2317/734 , G01N33/57423 , G01N33/5743 , G01N33/57476 , G01N33/57488
摘要： The present invention relates to methods which utilize anti-idiotypic antibodies, or fragments thereof, for tumor immunotherapy or immunoprophylaxis. Monoclonal anti-idiotypic antibodies which recognize an idiotype present on a second antibody or on a T lymphocyte or on an immune suppressor factor which is directed against a defined tumor antigen, can be used for immunization against a tumor, for immune anti-tumor activation or inhibition of suppression, or for in vitro activation of lymphocytes to be used in adoptive immunotherapy. The anti-idiotypic antibodies, or fragments thereof, can also be used to monitor anti-antibody induction in patients undergoing passive immunization to a tumor antigen by administration of anti-tumor antibody. In another embodiment, administration of T lymphocytes which express an idiotype directed against a defined tumor antigen can be used to transfer delayed-type hypersensitivity to the tumor. In another method of the invention, the induction of anti-idiotypic antibodies in vivo by administration of anti-tumor antibody or immune cells or factors exhibiting an anti-tumor idiotype can be therapeutically valuable.
摘要翻译： 本发明涉及利用抗独特型抗体或其片段用于肿瘤免疫治疗或免疫预防的方法。 识别存在于第二抗体或T淋巴细胞上的独特型单克隆抗单克隆抗体或针对定义的肿瘤抗原的免疫抑制因子的单克隆抗独特型抗体可用于针对肿瘤的免疫，用于免疫抗肿瘤活化或 抑制或抑制用于过继免疫治疗的淋巴细胞的体外活化。 抗独特型抗体或其片段也可以用于监测通过施用抗肿瘤抗体进行对肿瘤抗原的被动免疫的患者的抗 - 抗体诱导。 在另一个实施方案中，可以使用表达针对定义的肿瘤抗原的独特型的T淋巴细胞的施用来将延迟型超敏反应转移至肿瘤。 在本发明的另一种方法中，通过施用抗肿瘤抗体或免疫细胞或显示抗肿瘤独特型的因子在体内诱导抗独特型抗体可以具有治疗价值。
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