公开(公告)号：EP2646051A4

公开(公告)日：2014-05-28

申请号：EP11844824

申请日：2011-12-02

申请人： ONCOLYTICS BIOTECH INC

发明人： COFFEY MATTHEW C ,  SERL SARAH ,  PAVLIV LEO

IPC分类号： A61K39/15 ,  A61K9/08 ,  A61K31/70 ,  A61K48/00 ,  A61P31/12

CPC分类号： A61K35/765 ,  A61K35/76 ,  A61K39/15 ,  A61K2039/525 ,  C12N7/00 ,  C12N2720/12051 ,  C12N2720/12211 ,  C12N2720/12232 ,  C12N2720/12251

摘要： Provided herein are liquid viral formulations useful for the stabilization and storage of viruses and methods of preparing these formulations. The liquid viral formulations described herein include a virus (e.g., a purified virus) and a non-viral composition including excipients and a liquid carrier. The formulations can be used, for example, to retain the infectivity or immunogenicity of viruses during periods of storage.

公开(公告)号：EP2646052A4

公开(公告)日：2014-01-08

申请号：EP11845053

申请日：2011-12-02

申请人： ONCOLYTICS BIOTECH INC

发明人： COFFEY MATTHEW C ,  SERL SARAH ,  PAVLIV LEO

IPC分类号： A61K39/15 ,  A61K9/08 ,  A61K31/70 ,  A61K48/00 ,  A61P31/00 ,  A61P31/12

CPC分类号： A61K47/26 ,  A61K9/0019 ,  A61K9/19 ,  A61K35/00 ,  A61K35/76 ,  A61K35/765 ,  A61K35/768 ,  A61K47/02 ,  A61K47/183 ,  C12N7/00 ,  C12N2720/12051 ,  C12N2720/12251

摘要： Provided herein are lyophilized viral formulations useful for the stabilization and storage of viruses and methods of preparing these formulations. The lyophilized viral formulations described herein include a virus (e.g., a purified virus) and a non-viral composition including excipients. The formulations can be used, for example, to retain the infectivity or immunogenicity of viruses during periods of storage.

摘要翻译： 本文提供了可用于稳定和储存病毒的冻干病毒制剂和制备这些制剂的方法。 本文所述的冻干病毒制剂包括病毒（例如，纯化病毒）和包含赋形剂的非病毒组合物。 所述制剂可用于例如在储存期间保留病毒的感染性或免疫原性。

公开(公告)号：EP2702147A4

公开(公告)日：2014-11-05

申请号：EP12776970

申请日：2012-04-27

申请人： ONCOLYTICS BIOTECH INC

发明人： COFFEY MATTHEW C ,  HAGERMAN ALLISON ,  KAPADIA ROXNA ,  SERL SARAH

IPC分类号： B01D15/34 ,  C12N1/02

CPC分类号： B01D15/34 ,  B01D15/426 ,  C12N1/02 ,  C12N7/00 ,  C12N2720/12051

摘要： Provided herein are elution buffers and methods for purifying viruses using gel permeation chromatography. The methods are useful, for example, in increasing recovery of a virus from a gel permeation chromatography column. The buffers for use in the methods include at least one excipient selected from histidine or sucrose, a divalent cation, a non-ionic detergent, and a phosphate buffered saline.