公开(公告)号：EP1650182B1

公开(公告)日：2009-10-07

申请号：EP04747782.3

申请日：2004-07-14

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： IMAWAKA, Haruo c/o Ono Pharmaceutical Co., Ltd. ,  HASEGAWA, Tomoyuki c/o Ono Pharm. Co., Ltd. ,  SAKUYAMA, Shigeru c/o Ono Pharm. Co., Ltd. ,  KAWANAKA, Yasufumi c/o Ono Pharm. Co., Ltd. ,  AKIYAMA, Tsutomu c/o Ono Pharmaceutical Co., Ltd. ,  HOSHIKAWA, Masamitsu c/o Ono Pharm. Co., Ltd. ,  MATSUDA, Saiko c/o Ono Pharmaceutical Co., Ltd.

IPC分类号： C07C55/02 ,  C07C59/01 ,  C07C59/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/366 ,  A61K45/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07C59/185 ,  C07C59/01

摘要： A compound represented by the general formula (I): (wherein R represents optionally protected hydroxy or oxo; indicates alpha configuration, beta configuration, or a mixture of these in an arbitrary proportion; n is an integer of 1 to 3; and m is an integer of 0 to 10, provided that two or more R 's are not bonded to the same carbon atom other than the terminal carbon atoms), a salt of the compound, or a prodrug of either. The compound represented by the general formula (I) is effective in, e.g., improving the function of astrocytes. It is useful as a preventive and/or therapeutic agent for brain infarction or nerve function disorders after brain infarction and for neurodegenerative diseases such as Parkinson's disease, Parkinson's syndrome, amyotrophic lateral sclerosis, and Alzheimer's disease.

公开(公告)号：EP1650182A1

公开(公告)日：2006-04-26

申请号：EP04747782.3

申请日：2004-07-14

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： IMAWAKA, Haruo c/o Ono Pharmaceutical Co., Ltd. ,  HASEGAWA, Tomoyuki c/o Ono Pharm. Co., Ltd. ,  SAKUYAMA, Shigeru c/o Ono Pharm. Co., Ltd. ,  KAWANAKA, Yasufumi c/o Ono Pharm. Co., Ltd. ,  AKIYAMA, Tsutomu c/o Ono Pharmaceutical Co., Ltd. ,  HOSHIKAWA, Masamitsu c/o Ono Pharm. Co., Ltd. ,  MATSUDA, Saiko c/o Ono Pharmaceutical Co., Ltd.

IPC分类号： C07C55/02 ,  C07C59/01 ,  C07C59/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/366 ,  A61K45/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07C59/185 ,  C07C59/01

摘要： The present invention relates to a compound represented by formula (I)

wherein R 1 represents optionally protected hydroxy or oxo, indicates α-configuration, β-configuration or a mixture of these in an arbitary proportion, n represents an integer of 1 to 3, and m represents 0 or an integer of 1 to 10; and wherein two or more R 1 's are not bound to the same carbon atom other than the terminal carbon atom, a salt thereof or a prodrug thereof. The compounds represented by formula (I) have an ability to improve astrocyte function, and they are useful as a preventive and/or therapeutic agent for a brain infarction, neuronal dysfunction by brain infarction, Parkinson's disease, Parkinson's syndrome, amyotrophic lateral sclerosis or Alzheimer's disease.

摘要翻译： 本发明涉及由式（I）表示的化合物，其中R 1表示任选被保护的羟基或氧代，表示α-构型，β-构型或它们的混合物以任意比例存在，n表示1至3的整数，以及 m表示0或1至10的整数; 并且其中两个或更多个R 1不结合于除末端碳原子以外的相同碳原子，其盐或其前药。 由式（I）表示的化合物具有改善星形胶质细胞功能的能力，并且它们可用作脑梗塞的预防和/或治疗剂，由脑梗塞导致的神经元功能障碍，帕金森病，帕金森综合征，肌萎缩性侧索硬化症或阿尔茨海默病 疾病。