-
1.发明公开N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation 有权的N- Phenylarylsulfonamidverbindung，含有该化合物作为活性成分的，中间的化合物和方法及其制备药物
公开(公告)号：EP1612208A2
公开(公告)日：2006-01-04
申请号：EP05109059.5
申请日：2002-03-11
发明人： Naganawa, Atsushi , Saitoh, Tetsuji , Kobayashi, Kaoru , Maruyama, Takayuki , Nakai, Yoshihiko , Hashimoto, Shinsuke
IPC分类号： C07D213/70 , C07D277/36 , C07D307/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D405/12 , A61K31/341 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61P13/02
CPC分类号： C07D213/70 , C07D277/36 , C07D307/64 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： An N-phenylarylsulfonylamide compound of formula (I)
(R 1 is COOH etc .; R 2 is hydrogen, methyl, etc .; R 3 and R 4 are a combination of methyl and methyl, etc .; R 5 is isopropyl etc .; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E 2 receptor, especially an EP 1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.摘要翻译： 式（I）的N- phenylarylsulfonylamide化合物（R 1是COOH等; R 2为氢，甲基，等; R 3和R 4是甲基和甲基的组合，等等; R 5为异丙基等。 Ar是噻唑基，吡啶基，5-甲基-2-呋喃基各自与甲基OPTIONALLY substituiertem; n是零或1），的合成中间体的化合物及其制备方法。 式（I）的化合物结合到前列腺素E 2受体，尤其是爱到EP 1亚型受体，并拮抗它。 它较少受蛋白结合的影响，因此它在体内具有活性的令人满意的。 因此，它被认为是作为解热剂的镇痛剂，用于或抗肿瘤剂的尿频（尿频）和/或下泌尿道疾病综合征的治疗的药剂。
-
2.发明授权N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation 有权的N- Phenylarylsulfonamidverbindung，含有该化合物作为活性成分的，中间的化合物和方法及其制备药物
公开(公告)号：EP1612208B1
公开(公告)日：2011-08-31
申请号：EP05109059.5
申请日：2002-03-11
发明人： Naganawa, Atsushi , Saitoh, Tetsuji , Kobayashi, Kaoru , Maruyama, Takayuki , Nakai, Yoshihiko , Hashimoto, Shinsuke
IPC分类号： C07D307/64 , C07D277/36 , C07D213/71 , C07D405/12 , C07D417/12 , C07D401/12 , C07D413/12 , A61K31/341 , A61K31/426 , A61K31/4402 , A61K31/4406 , C07D213/70 , A61P13/02
CPC分类号： C07D213/70 , C07D277/36 , C07D307/64 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
-
3.发明公开N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation 有权的N- Phenylarylsulfonamidverbindung，含有该化合物作为活性成分的，中间的化合物和方法及其制备药物
公开(公告)号：EP1612208A3
公开(公告)日：2006-12-06
申请号：EP05109059.5
申请日：2002-03-11
发明人： Naganawa, Atsushi , Saitoh, Tetsuji , Kobayashi, Kaoru , Maruyama, Takayuki , Nakai, Yoshihiko , Hashimoto, Shinsuke
IPC分类号： C07D307/64 , C07D277/36 , C07D213/71 , C07D405/12 , C07D417/12 , C07D401/12 , C07D413/12 , A61K31/341 , A61K31/426 , A61K31/4402 , A61K31/4406 , C07D213/70 , A61P13/02
CPC分类号： C07D213/70 , C07D277/36 , C07D307/64 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： An N-phenylarylsulfonylamide compound of formula (I)
(R 1 is COOH etc .; R 2 is hydrogen, methyl, etc .; R 3 and R 4 are a combination of methyl and methyl, etc .; R 5 is isopropyl etc .; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E 2 receptor, especially an EP 1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
-
-
搜索结果
3 条记录 (耗时 0.011 秒)
