公开(公告)号：EP0960641A4

公开(公告)日：2002-02-20

申请号：EP98943011

申请日：1998-09-17

申请人： ORGANO CORP

发明人： KANEKO KIKUZO ,  MASUDA TAKAYUKI ,  MATSUDA FUMIHIKO ,  SATO KOHEI ,  TANIKAWA KOUJI

IPC分类号： B01D15/08 ,  B01D15/18 ,  B01D15/00 ,  B01D15/02

CPC分类号： B01D15/1828 ,  B01D15/361 ,  B01D2215/023

摘要： A method for chromatographic separation wherein components contained in a liquid feedstock or the like are separated by passing the feedstock through a packing layer which is regulated in the degree of separation between the components by using two or more kinds of packings different in the degree of separation between the components in an intermingled state, thus giving fractions enriched in the components respectively at high purities and high recoveries with a decreased amount of use of the desorbing agent such as eluent; and equipment for chromatographic separation wherein three or more components can be separated by using a first packing exhibiting a high degree of separation between a medium-affinity component and a weak-affinity one and a second packing exhibiting a high degree of separation between a strong-affinity component and a medium-affinity one in an intermingled state to regulate the degree of separation of the packing layer between respective two of the three components, thus giving three or more fractions enriched in the respective component.

公开(公告)号：EP1003036A4

公开(公告)日：2002-12-18

申请号：EP99922518

申请日：1999-05-27

申请人： ORGANO CORP

发明人： MASUDA TAKAYUKI ,  KANEKO KIKUZO ,  SATO KOHEI ,  MATSUDA FUMIHIKO

IPC分类号： G01N30/46 ,  B01D15/08 ,  B01D15/18 ,  G01N30/88 ,  B01D15/00 ,  B01D15/02

CPC分类号： B01D15/1828 ,  B01D2215/023

摘要： A method of chromatography in which a chromatograph having a circulation system comprising unit packing layers (1) to (4) endlessly connected in series is used for separating three ingredients A, B, and C whose affinity for the packing is in the order of C>B>A, which comprises a step (1) as the first stage in which the following operations } } } } are conducted and a subsequent step (2) as the second to fourth stages which comprises three repetitions of the following operations } } , the liquid introduction point and the liquid discharge point each being shifted by one unit layer toward the downstream side in the circulation system after every stage: the circulation system is interrupted, and all the ingredient B fraction is discharged from the upstream side of the interruption point while supplying a feed fluid f to the unit packing layer on the immediately downstream side of the interruption point and further supplying an eluent D to the circulation system; the ingredient A fraction is partly discharged while supplying the eluent D to the circulation system; the ingredient C fraction is partly discharged while supplying the eluent D to the circulation system; and liquid circulation is conducted through the circulation system without conducting liquid supply to the system or liquid discharge therefrom.

公开(公告)号：EP1336610A4

公开(公告)日：2006-05-17

申请号：EP01997483

申请日：2001-11-21

申请人： ORGANO CORP

发明人： KANEKO KIKUZO ,  IKUSHIMA HEIJI

IPC分类号： B01D15/00 ,  B01D15/18 ,  B01D15/32 ,  C07D311/72 ,  G01N30/46 ,  G01N30/88 ,  B01D15/08

CPC分类号： B01D15/185 ,  B01D15/1864 ,  B01D15/325 ,  C07D311/72

摘要： A simulated moving bed type chromatographic separation apparatus is provided in which a plurality of columns each filled with a hydrophobic adsorbent for reversed-phase liquid chromatography having a relatively low affinity for tocotrienol than that for tocopherol are connected cyclically and in series. To the chromatographic separation apparatus, a raw material fluid containing at least several tens of percent of tocopherol and tocotrienol and consisting substantially 100% of oil constituents and an eluent of ethanol-water = 90/10 are supplied so that a fraction fluid enriched with tocotrienol is separated from tocopherol. With this configuration, preparation of tocotrienol from a raw material fluid containing a large amount of tocopherol and tocotrienol can be achieved in a commercial scale through a method not too different from the conventionally known simulated moving bed type chromatographic separation and the initial investment cost and running cost can be reduced.

摘要翻译： 提供了一种模拟移动床型色谱分离装置，其中每个充满反相液相色谱的疏水性吸附剂的多个柱与生育酚相比具有相对低的生育三烯酚的亲和力，其循环和串联连接。 向色谱分离装置中提供含有至少几十％生育酚和生育三烯酚并且基本上100％的油成分和乙醇 - 水= 90/10的洗脱液的原料流体，使得富含生育三烯酚的级分流体 与生育酚分离。 通过这种结构，可以通过与常规已知的模拟移动床型色谱分离和初始投资成本和运行不同的方法以商业规模实现来自含有大量生育酚和生育三烯酚的原料流体的生育三烯酚的制备 成本可以降低。