公开(公告)号：EP1351666A1

公开(公告)日：2003-10-15

申请号：EP02710900.8

申请日：2002-01-18

申请人： ORION CORPORATION (ORION-YHTYMA OY)

发明人： WATANABE, Wiwik ,  KAUPPINEN, Esko ,  AHONEN, Petri ,  BROWN, David ,  MUTTONEN, Esa

IPC分类号： A61K9/14 ,  A61K9/12 ,  A61J3/02

CPC分类号： A61K9/5192 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01J13/0004

摘要： The invention relates to free nano-sized particles of active agents e.g. therapeutic, cosmetic or diagnostic agents, and to a method for the preparation of such particles. The method comprises providing a liquid feed stock comprising an active agent or combination of two or more active agents, atomising the liquid feed stock, suspending the droplets in a carrier gas, and passing the carrier gas and droplets through a heated tube flow reactor under predetermined residence time and temperature history, and collecting the particles produced. Nano-sized crystalline spherical uncharged particles with narrow aerodynamic particle size distribution and rough surfaces, are obtained. The particles show improved dissolution rate in-vitro and bioavailability in-vivo, dispersibility and stability.