公开(公告)号：EP4382912A1

公开(公告)日：2024-06-12

申请号：EP22849488.6

申请日：2022-07-26

Applicant: OSAKA UNIVERSITY

Inventor： HIKITA, Hayato ,  MYOJIN, Yuta ,  TAKEHARA, Tetsuo

IPC: G01N33/574 ,  C12Q1/6851 ,  C12Q1/686 ,  G01N33/53 ,  G01N33/543 ,  G01N33/576 ,  G01N33/68

CPC classification number: C12Q1/6851 ,  C12Q1/686 ,  G01N33/543 ,  G01N33/53 ,  G01N33/574 ,  G01N33/68 ,  G01N33/576

Abstract: The method of the present invention for evaluating the risk of developing liver cancer in a subject includes (1) a step of measuring a GDF15 level of a subject and (2) a step of relating the GDF15 level to the risk of developing liver cancer. When the GDF15 level measured in step (1) is not less than a cutoff value set in advance, the GDF15 level becomes an indicator that the subject has a high risk of developing liver cancer, and when the GDF15 level is less than the cutoff value, it becomes an indicator that the risk of developing liver cancer is low. The present invention also provides a kit for measuring GDF15 levels in a subject for use in the method of the present invention, and a diagnostic agent for evaluating the risk of developing liver cancer in a subject, which contains an anti-GDF15-specific antibody.

公开(公告)号：EP4549942A1

公开(公告)日：2025-05-07

申请号：EP23831123.7

申请日：2023-06-15

Applicant: OSAKA UNIVERSITY

Inventor： HIKITA, Hayato ,  SAKANE, Sadatsugu ,  TAKEHARA, Tetsuo ,  FUKUMOTO, Kenji

IPC: G01N33/574 ,  C12Q1/68

Abstract: The present invention provides a method for testing a possibility of liver cancer development. A method for testing a possibility of liver cancer development includes step (1) of detecting at least one target molecule selected from the group consisting of Fibulin-3, GPNMB, Fibulin-3 mRNA, and GPNMB mRNA in a biological sample collected from a subject.