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1.发明公开Stable polymorph of N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof 审中-公开N-（3-乙炔基苯基氨基）-6,7-双（2-甲氧基乙氧基）-4-喹唑啉胺盐酸盐的稳定多晶型物，生产方法及其药物用途
公开(公告)号：EP2168581A3
公开(公告)日：2010-07-21
申请号：EP09150479.5
申请日：2000-11-09
发明人： Connell, Richard, D. , Moyer, James, D. , Morin, Michael, J. , Kajiji, Shama, M. , Foster, Barbara, A. , Ferrante, Karen, J. , Norris, Timothy , Raggon, Jeffrey, W. , Silberman, Sandra, L.
IPC分类号： A61K31/505 , C07D239/94
CPC分类号： A61K45/06 , A61K31/517 , C07D239/94 , A61K2300/00
摘要： The present invention relates to crystalline forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, their production in essentially pure form, and their use. The invention also relates to the pharmaceutical compositions containing the crystalline forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
摘要翻译： N-（3-乙炔基苯基）-6,7-双（2-甲氧基乙氧基）-4-喹唑啉胺盐酸盐的结晶形式及其用途本发明涉及N-（3-乙炔基苯基）-6,7-双（2-甲氧基乙氧基）-4-喹唑啉胺盐酸盐的结晶形式及其用途。 本发明还涉及含有作为盐酸盐的N-（3-乙炔基苯基）-6,7-双（2-甲氧基乙氧基）-4-喹唑啉胺的结晶形式的药物组合物以及通过以下方法治疗过度增殖性疾病如癌症的方法： 给予化合物。
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2.发明公开Stable polymorph of N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof 审中-公开N-（3-乙炔基 - 苯基氨基）-6,7-双 - 的稳定的多晶形式（2-甲氧基乙氧基）-4-喹唑啉胺盐酸盐，制造工艺和药物用途及其
公开(公告)号：EP2168581A9
公开(公告)日：2011-07-20
申请号：EP09150479.5
申请日：2000-11-09
发明人： Connell, Richard, D. , Moyer, James, D. , Morin, Michael, J. , Kajiji, Shama, M. , Foster, Barbara, A. , Ferrante, Karen, J. , Norris, Timothy , Raggon, Jeffrey, W. , Silberman, Sandra, L.
IPC分类号： A61K31/505 , C07D239/94
CPC分类号： A61K45/06 , A61K31/517 , C07D239/94 , A61K2300/00
摘要： The present invention relates to crystalline forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, their production in essentially pure form, and their use. The invention also relates to the pharmaceutical compositions containing the crystalline forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
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3.发明公开Stable polymorph of N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof 审中-公开N-（3-乙炔基 - 苯基氨基）-6,7-双 - 的稳定的多晶形式（2-甲氧基乙氧基）-4-喹唑啉胺盐酸盐，制造工艺和药物用途及其
公开(公告)号：EP2168581A2
公开(公告)日：2010-03-31
申请号：EP09150479.5
申请日：2000-11-09
发明人： Connell, Richard, D. , Moyer, James, D. , Morin, Michael, J. , Kajiji, Shama, M. , Foster, Barbara, A. , Ferrante, Karen, J. , Norris, Timothy , Raggon, Jeffrey, W. , Silberman, Sandra, L.
IPC分类号： A61K31/505 , C07D239/94
CPC分类号： A61K45/06 , A61K31/517 , C07D239/94 , A61K2300/00
摘要： The present invention relates to crystalline forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, their production in essentially pure form, and their use. The invention also relates to the pharmaceutical compositions containing the crystalline forms of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
摘要翻译： 本发明涉及N-（3-乙炔基苯基）-6,7-双（2-甲氧基乙氧基）-4-喹唑啉胺盐酸盐，它们在本质上纯的形式生产，并且它们的使用的结晶形式。 因此，本发明涉及含有N-（3-乙炔基苯基）-6,7-双（2-甲氧基乙氧基）-4-喹唑啉胺盐酸盐的结晶形式，药物组合物和治疗过度增殖性疾病，：如癌症的方法，通过 给予化合物。
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