公开(公告)号：EP1285923A4

公开(公告)日：2004-02-11

申请号：EP01955652

申请日：2001-08-10

申请人： OTSUKA CHEMICAL CO LTD ,  TAIHO PHARMACEUTICAL CO LTD

发明人： SHIMABAYASHI A ,  KAWAHARA I

IPC分类号： A61P31/04 ,  C07D499/00 ,  C07D499/18 ,  C07D499/44 ,  C07D499/86 ,  C07D499/87 ,  C07D499/897

CPC分类号： C07D499/00

摘要： Stable crystals of diphenylmethyl 2-methyl-2-triazolyl-methylpenam-3-carboxylate, which cause substantially no decomposition or deterioration even after allowing to stand at room temperature for one year. The crystals are produced by concentrating a solution of diphenylmethyl 2-methyl-2-triazolylmethylpenam-3-carboxylate of formula (2), diluting the resulting concentrate with an acetic ester, and mixing the obtained dilution with hexane or a hexane/acetic ester mixture to crystallize diphenylmethyl 2-methyl-2-triazolylmethyl-penam-3-carboxylate wherein Ph is phenyl.