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1.发明公开PENICILLIN CRYSTAL AND PROCESS FOR PRODUCING THE SAME 有权PENICILLINKRISTALL UND VERFAHREN ZU DESSEN HERSTELLUNG
公开(公告)号：EP1671974A1
公开(公告)日：2006-06-21
申请号：EP04773756.4
申请日：2004-10-08
IPC分类号： C07D499/00
CPC分类号： C07D499/86
摘要： The present invention provides 2β-chloromethyl-2α-methylpenam-3α-carboxylic acid benzhydryl ester (CMPB) crystals of excellent stability, and a process for producing the CMPB crystals comprising the steps of (A) concentrating a solution containing CMPB; (b) subjecting the thus-obtained concentrate to column chromatography; (C) concentrating a CMPB-containing fraction; and (D) dissolving the thus-obtained CMPB-containing concentrate in an ether solvent and adding a hydrocarbon solvent to the resulting solution to precipitate CMPB crystals.
摘要翻译： 本发明提供了具有优异稳定性的2β-氯甲基-2± - 甲基氨基-3'-羧酸二苯甲基酯（CMPB）晶体，以及制备CMPB晶体的方法，包括以下步骤：（A）浓缩含有CMPB的溶液; （b）将由此得到的浓缩物进行柱色谱; （C）浓缩含CMPB的级分; 和（D）将由此获得的含CMPB的浓缩物溶解在醚溶剂中并向所得溶液中加入烃溶剂以沉淀CMPB晶体。
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公开(公告)号：EP1671974B1
公开(公告)日：2010-12-08
申请号：EP04773756.4
申请日：2004-10-08
IPC分类号： C07D499/00
CPC分类号： C07D499/86
摘要： 2β-chloromethyl-2α-methylpenam-3α-carboxylic acid benzhydryl ester (CMPB) crystals having excellent stability; and a process for producing CMPB crystals which comprises (A) the step of concentrating a CMPB-containing solution, (B) the step of subjecting the resultant concentrate to column chromatography, (C) the step of concentrating a CMPB-containing fraction, and (D) the step of dissolving the resultant CMPB-containing concentrate in an ether solvent and subsequently adding a hydrocarbon solvent to this solution to precipitate CMPB crystals.
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