公开(公告)号：EP1273587B1

公开(公告)日：2009-06-10

申请号：EP01919924.9

申请日：2001-04-13

申请人： OTSUKA KAGAKU KABUSHIKI KAISHA

发明人： KAMEYAMA, Yutaka, c/o OTSUKA KAGAKU K.K. ,  FUKAE, Kazuhiro, c/o OTSUKA KAGAKU K.K.

IPC分类号： C07D501/04 ,  C07D501/22

CPC分类号： C07D501/00

摘要： A process for the preparation of a 3-vinylcephem compound, characterized by treating a protected 3-vinylcephem derivative of the general formula (1) in an organic solvent in the presence of a perhalogenic acid and an organic protonic acid to thereby obtain a 3-vinylcephem compound of formula (2). In general formula (1), R?1, R2 and R3¿ are each hydrogen or optionally substituted arylmethyl, with the proviso that all of R?1, R2 and R3¿ must not be hydrogen.

公开(公告)号：EP1273587A1

公开(公告)日：2003-01-08

申请号：EP01919924.9

申请日：2001-04-13

申请人： OTSUKA KAGAKU KABUSHIKI KAISHA

发明人： KAMEYAMA, Yutaka, c/o OTSUKA KAGAKU K.K. ,  FUKAE, Kazuhiro, c/o OTSUKA KAGAKU K.K.

IPC分类号： C07D501/04 ,  C07D501/22

CPC分类号： C07D501/00

摘要： A process for preparing 3-vinyl-cephem compound of the formula (2), the process comprising the step of treating protected 3-vinyl-cephem derivative of the formula (1) in an organic solvent in the presence of perhalogenated acid and an organic protonic acid
wherein each of R 1 , R 2 and R 3 is a hydrogen atom or arylmethyl group optionally having a substituent, provided that R 1 , R 2 and R 3 can not be a hydrogen atom at the same time.

摘要翻译： 一种制备式（2）的3-乙烯基头孢烯化合物的方法，该方法包括在有机溶剂中，在全卤酸和有机物存在下，将式（1）的被保护的3-乙烯基头孢烯衍生物 其中R 1，R 2和R 3各自为任选具有取代基的氢原子或芳基甲基，条件是R 1，R 2和R 3均为氢原子， 不能同时成为氢原子。