公开(公告)号：EP1227100A4

公开(公告)日：2003-03-05

申请号：EP00962912

申请日：2000-09-28

申请人： OTSUKA KAGAKU KK

发明人： MORIYOSHI TAKASHI ,  UOSAKI YASUHIRO ,  KAMEYAMA YUTAKA ,  SUZUKI DAISUKE ,  SEO YOSHIKO

IPC分类号： C07D501/00 ,  C07D501/12 ,  C07D501/24

CPC分类号： C07D501/00 ,  Y02P20/544

摘要： A method for preparing crystals of a 3-cephem derivative, characterized in that it comprises subjecting a 3-cephem derivative in the form of an amorphous powder or an oil to a crystallization by the use of a good solvent and a poor solvent comprising carbon dioxide in a supercritical or subcritical state, thereby giving a 3-cephem derivative in a crystaline state; and crystals of a 3-cephem derivative.