公开(公告)号：EP1300160A1

公开(公告)日：2003-04-09

申请号：EP01932213.0

申请日：2001-05-23

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： TOMOHIRA, Yuso ,  MUKAI, Tadashi ,  KASHIMOTO, Minoru ,  NAGASAWA, Masakazu ,  ICHIBA, Tetsuroh ,  KURIBAYASHI, Daisuke ,  OKA, Yoshikazu ,  TOGUCHI, Hajime

IPC分类号： A61K47/20 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24

CPC分类号： A61K9/2054 ,  A61K9/2013 ,  A61K47/02 ,  A61K47/20

摘要： Disclosed is a method for stabilizing a solid pharmaceutical preparation containing a pharmacological substance and sodium lauryl sulfate, the method comprising incorporating into the preparation at least one member selected from the group consisting of neutral salts, basic salts and basic substances. The preparation containing sodium lauryl sulfate prepared by the method of the invention has superior performance, including high storage stability, suppression of discoloration and deterioration, and prevention of change in its properties, such as the dissolution rate of pharmacological substance from the preparation.

摘要翻译： 公开了一种稳定含有药理学物质和十二烷基硫酸钠的固体药物制剂的方法，该方法包括将至少一种选自中性盐，碱性盐和碱性物质的成分掺入制剂中。 通过本发明方法制备的含有十二烷基硫酸钠的制剂具有优异的性能，包括高储存稳定性，抑制变色和变质，以及防止其制备物质的药理学溶解速度等性质的改变。