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公开(公告)号：EP0941068A1
公开(公告)日：1999-09-15
申请号：EP97913531.0
申请日：1997-11-17
申请人： OctoPlus B.V.
CPC分类号： A61K47/36 , A61K9/1652
摘要： The present invention relates to a process for the preparation of a controlled release system, comprising forming of an aqueous two-phase system from at least two water soluble polymers, which polymers are incompatible in solution, at least one of these polymers being cross-linkable, the cross-linkable polymer phase being emulsified in the other polymer phase; adding at least one releasable compound which is soluble in the cross-linkable polymer phase in the aqueous solution, allowing the releasable compound to diffuse in the cross-linkable polymer phase; cross-linking the cross-linkable polymer before or after the releasable compound is added, preferably to a degree that the pores in the cross-linked structure are substantially smaller than the particles size of the releasable compound; and separating the cross-linked structures enclosing the releasable compound from the other phase. Further, the invention relates to microspheres, at least 80 wt.% thereof having a particle size of between 100 nanometer and 1000 νm, which microspheres are comprised of a degradable, cross-linked polymer encapsulating at least one releasable compound, the pore size of the cross-linked polymer being smaller than the particle size of the releasable compound.
摘要翻译： 本发明涉及制备控制释放系统的方法，包括由至少两种水溶性聚合物形成水性两相体系，所述聚合物在溶液中不相容，这些聚合物中的至少一种可交联 ，可交联聚合物相在另一聚合物相中乳化; 在水溶液中加入至少一种可溶于可交联聚合物相的可释放化合物，使可释放化合物在可交联聚合物相中扩散; 在加入可释放化合物之前或之后使可交联聚合物交联，优选达到交联结构中的孔基本上小于可释放化合物的粒径的程度; 并将包封可释放化合物的交联结构与另一相分离。 此外，本发明涉及微球体，其至少80重量％具有100纳米至1000νm的粒径，该微球体包含包封至少一种可释放化合物的可降解交联聚合物，其孔尺寸为 交联聚合物小于可释放化合物的粒径。
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公开(公告)号：EP0941068B1
公开(公告)日：2004-05-26
申请号：EP97913531.6
申请日：1997-11-17
申请人： OctoPlus B.V.
IPC分类号： A61K9/16
CPC分类号： A61K47/36 , A61K9/1652
摘要： The present invention relates to a process for the preparation of a controlled release system, comprising forming of an aqueous two-phase system from at least two water soluble polymers, which polymers are incompatible in solution, at least one of these polymers being cross-linkable, the cross-linkable polymer phase being emulsified in the other polymer phase; adding at least one releasable compound which is soluble in the cross-linkable polymer phase in the aqueous solution, allowing the releasable compound to diffuse in the cross-linkable polymer phase; cross-linking the cross-linkable polymer before or after the releasable compound is added, preferably to a degree that the pores in the cross-linked structure are substantially smaller than the particles size of the releasable compound; and separating the cross-linked structures enclosing the releasable compound from the other phase. Further, the invention relates to microspheres, at least 80 wt.% thereof having a particle size of between 100 nanometer and 1000 mu m, which microspheres are comprised of a degradable, cross-linked polymer encapsulating at least one releasable compound, the pore size of the cross-linked polymer being smaller than the particle size of the releasable compound.
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