公开(公告)号：EP2341345A1

公开(公告)日：2011-07-06

申请号：EP10015839.3

申请日：2005-08-18

申请人： Odyssey Thera, Inc.

发明人： Westwick, John ,  Yu, Helen ,  MacDonald, Marnie L.

IPC分类号： G01N33/50 ,  C12Q1/02

CPC分类号： C12Q1/025 ,  G01N33/5023 ,  G01N33/5035 ,  G01N33/5041 ,  G01N33/5097 ,  G01N2440/00 ,  G01N2440/10 ,  G01N2440/12 ,  G01N2440/36 ,  G01N2440/38 ,  G01N2500/10

摘要： The instant invention provides a method for establishing safety profiles for chemical compounds, as well as pharmacological profiling said method comprising (A) testing the effects of said chemical compounds on the amount and/or post-translational modifications of two or more macromolecules in intact cells; (B) constructing a pharmacological profile based on the results of said tests; and (C) comparing said profile to the profile(s) of drugs with established safety characteristics. Additionally, the invention is also directed to a composition comprising an assay panel, said panel comprising at least one high-content assay for the amount and/or post-translational modification of a protein and at least one high-content assay for the amount and/or subcellular location of a protein-protein interaction.

摘要翻译： 本发明提供了一种用于建立化学化合物的安全性的方法以及药理学分析，所述方法包括（A）测试所述化合物对完整细胞中两种或更多种大分子的量和/或翻译后修饰的影响 ; （B）基于所述测试的结果构建药理学特征; 和（C）将所述概况与具有确定的安全特征的药物的概况进行比较。 此外，本发明还涉及包含测定面板的组合物，所述面板包含至少一种用于蛋白质的量和/或翻译后修饰的高含量测定，以及至少一种高含量测定法，其量为和 /或蛋白质 - 蛋白质相互作用的亚细胞位置。

公开(公告)号：EP2363496A1

公开(公告)日：2011-09-07

申请号：EP10015840.1

申请日：2005-08-18

申请人： Odyssey Thera, Inc.

发明人： Westwick, John ,  Yu, Helen ,  MacDonald, Marnie L.

IPC分类号： C12Q1/02 ,  G01N33/50

CPC分类号： C12Q1/025 ,  G01N33/5023 ,  G01N33/5035 ,  G01N33/5041 ,  G01N33/5097 ,  G01N2440/00 ,  G01N2440/10 ,  G01N2440/12 ,  G01N2440/36 ,  G01N2440/38 ,  G01N2500/10

摘要： The instant invention provides a method for establishing safety profiles for chemical compounds, as well as pharmacological profiling said method comprising (A) testing the effects of said chemical compounds on the amount and/or post-translational modifications of two or more macromolecules in intact cells; (B) constructing a pharmacological profile based on the results of said tests; and (C) comparing said profile to the profile(s) of drugs with established safety characteristics. Additionally, the invention is also directed to a composition comprising an assay panel, said panel comprising at least one high-content assay for the amount and/or post-translational modification of a protein and at least one high-content assay for the amount and/or subcellular location of a protein-protein interaction.

摘要翻译： 本发明提供了建立化学化合物安全性概况的方法以及药理概况分析，所述方法包括（A）测试所述化学化合物对完整细胞中两种或更多种大分子的量和/或翻译后修饰的影响 ; （B）基于所述测试的结果构建药理学特征; 和（C）将所述特征与具有确定安全特征的药物特征进行比较。 此外，本发明还涉及包含测定组的组合物，所述组包含至少一种蛋白质的量和/或翻译后修饰的高含量测定和至少一种高含量测定的量以及 /或蛋白质 - 蛋白质相互作用的亚细胞定位。