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1.发明公开EHRLICHIAL INVASIN FOR IMMUNIZATION, DIAGNOSIS, AND CELL DELIVERY 审中-公开EHRLICHIALES侵袭针对免疫接种，诊断和细胞释放
公开(公告)号：EP2925352A1
公开(公告)日：2015-10-07
申请号：EP13859849.5
申请日：2013-12-03
IPC分类号： A61K39/00
CPC分类号： A61K39/0233 , A61K39/385 , A61K47/646 , C07K14/29 , C07K2319/80 , G01N33/56911 , G01N33/6854 , G01N2333/29 , G01N2469/20 , G01N2800/52 , Y02A50/403
摘要： Disclosed are vaccines containing one or more immunogenic polypeptides derived from an EtpE protein from an Ehrlichia sp. or nucleic acid encoding these polypeptides. Also disclosed is a method for vaccinating a subject against Ehrlichia sp. that involves administering to the subject a composition comprising any of the disclosed vaccines. Also disclosed is a method for diagnosing and/or monitoring the treatment of Ehrlichiosis in a subject that comprising assaying a biological sample (e.g., blood, serum, or plasma sample) from the subject for the presence of an antibody that specifically binds an EtpE polypeptide. Also disclosed are methods for delivering a therapeutic or diagnostic agent to a cell in a subject that involves conjugating the agent, or a delivery vehicle comprising the agent, to polypeptide containing the C-terminal domain of an EtpE protein.
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