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    PROTEIN KINASE INHIBITORS
    1.
    发明授权
    PROTEIN KINASE INHIBITORS 有权
    蛋白激酶抑制剂

    公开(公告)号：EP1765351B1

    公开(公告)日：2009-03-04

    申请号：EP05744735.1

    申请日：2005-06-09

    申请人： Oncalis AG

    发明人： BERSET, Catherine ,  AUDETAT, Stephan ,  TIETZ, Julia ,  GUNDE, Tea ,  BARBERIS, Alcide ,  SCHUMACHER, Andreas ,  TRAXLER, Peter

    IPC分类号： A61K31/519 ,  A61K31/695 ,  A61P35/00

    CPC分类号： A61K31/519 ,  A61K31/695

    摘要： The present invention relates to the use of compounds for the treatment of disorders involving a protein kinase, preferably a tyrosine kinase. The compounds e.g. have the general formula (I) wherein R1, R2 and R4 are independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, NR6R7, OR6, SR6, (CH)mR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C3-C8 cycloalkyl, optionally substituted aryl, optionally substituted 5- or 6- membered heterocycle, (CH2)nCO(O)R8, (CH2)mR' where n = 0, 1, 2, 3, 4 and wherein R8 is hydrogen, C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted aryl and wherein R' is selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, optionally substituted aryl, halogen, hydroxyl, NO2, NH2, SO2NH2, cyano and m is 0, 1, 2, 3, 4; R3 is hydroxyl, halogen, NH2, NO2, cyano, SH, optionally substituted C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted aryl, optionally substituted 5- or 6-membered heterocycle, R5 is selected from C1-C6 alkyl, hydrogen, alkoxy, NH2, halogen, cyano, alkine, COOR'' wherein R'' is selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl.

    PROTEIN KINASE INHIBITORS
    3.
    发明公开
    PROTEIN KINASE INHIBITORS 有权
    PROTEINKINASEINHIBITOREN

    公开(公告)号：EP1765351A1

    公开(公告)日：2007-03-28

    申请号：EP05744735.1

    申请日：2005-06-09

    申请人： Oncalis AG

    发明人： BERSET, Catherine ,  AUDETAT, Stephan ,  TIETZ, Julia ,  GUNDE, Tea ,  BARBERIS, Alcide ,  SCHUMACHER, Andreas ,  TRAXLER, Peter

    IPC分类号： A61K31/519 ,  A61K31/695 ,  A61P35/00

    CPC分类号： A61K31/519 ,  A61K31/695

    摘要： The present invention relates to the use of compounds for the treatment of disorders involving a protein kinase, preferably a tyrosine kinase. The compounds e.g. have the general formula (I) wherein R1, R2 and R4 are independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, NR6R7, OR6, SR6, (CH)mR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C3-C8 cycloalkyl, optionally substituted aryl, optionally substituted 5- or 6- membered heterocycle, (CH2)nCO(O)R8, (CH2)mR' where n = 0, 1, 2, 3, 4 and wherein R8 is hydrogen, C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted aryl and wherein R' is selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, optionally substituted aryl, halogen, hydroxyl, NO2, NH2, SO2NH2, cyano and m is 0, 1, 2, 3, 4; R3 is hydroxyl, halogen, NH2, NO2, cyano, SH, optionally substituted C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted aryl, optionally substituted 5- or 6-membered heterocycle, R5 is selected from C1-C6 alkyl, hydrogen, alkoxy, NH2, halogen, cyano, alkine, COOR'' wherein R'' is selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl.