公开(公告)号：EP2852607A1

公开(公告)日：2015-04-01

申请号：EP13794398.1

申请日：2013-04-24

申请人： Oncology Research International Limited

发明人： MUSCROFT-TAYLOR, Andrew Clive ,  MARSHALL, Philip Andrew ,  MASON, Jennifer Mary ,  WALKER, David Millar

IPC分类号： C07J75/00 ,  C07J71/00 ,  A61K31/704 ,  A61K31/7048

CPC分类号： C07J17/005 ,  A61K31/7048 ,  C07H1/00 ,  C07H15/256 ,  C07H17/08 ,  C07J71/00 ,  C07J71/0005 ,  C07J75/00

摘要： The present invention provides an improved synthesis of a class of steroid saponins. Furthermore, the present invention provides a method of selectively discriminating between the C2 and C3 hydroxyl groups of a mono-glycosylated steroid saponin—a key step in the preparation of this class of compounds. Additionally, the present invention provides a range of steroid saponin derivatives, and methods of making them.

公开(公告)号：EP2852607B1

公开(公告)日：2018-10-24

申请号：EP13794398.1

申请日：2013-04-24

申请人： Oncology Research International Limited

发明人： MUSCROFT-TAYLOR, Andrew Clive ,  MARSHALL, Philip Andrew ,  MASON, Jennifer Mary ,  WALKER, David Millar

IPC分类号： C07J75/00 ,  C07J17/00 ,  C07J71/00 ,  A61K31/704 ,  A61K31/7048 ,  C07H1/00 ,  C07H15/256 ,  C07H17/08

CPC分类号： C07J17/005 ,  A61K31/7048 ,  C07H1/00 ,  C07H15/256 ,  C07H17/08 ,  C07J71/00 ,  C07J71/0005 ,  C07J75/00

摘要： The present invention provides an improved synthesis of a class of steroid saponins. Furthermore, the present invention provides a method of selectively discriminating between the C2 and C3 hydroxyl groups of a mono-glycosylated steroid saponin—a key step in the preparation of this class of compounds. Additionally, the present invention provides a range of steroid saponin derivatives, and methods of making them.