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公开(公告)号：EP2270051A3
公开(公告)日：2011-10-19
申请号：EP10176748.1
申请日：2004-01-22
发明人： Honjo, Tasuku , Shibayama, Shiro , Takeda, Kazuhiko , Matsuo, Masayoshi , Yoshida, Takao , Miyamoto, Masakazu
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
摘要翻译： 本发明涉及包含识别人PD-1的部分，识别人PD-1表达细胞的细胞膜中的膜蛋白的部分和接头的人PD-1特异性物质。 由于人PD-1特异性物质选择性地可以识别人PD-1和人PD-1表达细胞的细胞膜上的膜蛋白，并且可以传递人PD-1的抑制信号，因此它对于治疗和/或 预防由免疫病引起的疾病。
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公开(公告)号：EP2270051A2
公开(公告)日：2011-01-05
申请号：EP10176748.1
申请日：2004-01-22
发明人： Honjo, Tasuku , Shibayama, Shiro , Takeda, Kazuhiko , Matsuo, Masayoshi , Yoshida, Takao , Miyamoto, Masakazu
CPC分类号： C07K16/2818 , A61K39/3955 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/56 , C07K2317/73
摘要： The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
摘要翻译： 本发明涉及对人PD-1特异性的物质，其包含识别人PD-1的部分，识别人PD-1表达细胞的细胞膜中的膜蛋白的部分和接头。 由于对人PD-1特异性的物质可以选择性地识别人PD-1和人PD-1表达细胞的细胞膜上的膜蛋白，并且可以传递人PD-1的抑制信号，因此它可用于治疗和/或 预防免疫病引起的疾病。
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公开(公告)号：EP2270051B1
公开(公告)日：2019-05-15
申请号：EP10176748.1
申请日：2004-01-22
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