公开(公告)号：EP2370411A2

公开(公告)日：2011-10-05

申请号：EP09831228.3

申请日：2009-12-04

申请人： Oregon Health and Science University ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA D.B.A THE DEPARTMENT OF VETERANS AFFAIRS ,  University Of South Florida ,  Medicines for Malaria Venture

发明人： RISCOE, Michael,K. ,  KELLY, Jane, X. ,  WINTER, Rolf, W. ,  HINRICHS, David, J. ,  SMILKSTEIN, Martin, J. ,  NILSEN, Aaron ,  MONASTYRSKYI, Andrii ,  CROSS, Richard M. ,  BURROWS, Jeremy ,  KYLE, Dennis ,  MANETSCH, Roman ,  FLANIGAN, David L.

IPC分类号： C07D215/04 ,  C07D403/04 ,  C07D403/12 ,  A61P31/04

CPC分类号： C07D215/60 ,  C07D215/233 ,  C07D215/42 ,  C07D239/90 ,  C07D279/16 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D491/052

摘要： A method for inhibiting a parasitic or infectious disease in a subject, wherein the parasitic or infectious disease is selected from one caused by Eimeria sp., Babesia sp., Theileria sp. or Neospora caninum, the method comprising administering to the subject a therapeutically effective amount of a compound of formula I: or formula II: or a pharmaceutically acceptable salt of formula I or formula II, wherein: R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl; R2 is methyl, haloalkyl, or heteroaryl; R4 is hydroxyl, carbonyloxy, or carbonyldioxy; R3 is aliphatic, aryl, aralkyl, or alkylaryl; and R5, R6, R7 and R8 are each individually H, halogen, alkoxy, alkyl, haloalkyl, aryl, nitro, cyano, amino, amido, acyl, carboxyl, substituted carboxyl, or —SO2R10, wherein R10 is H, alkyl, amino or haloalkyl; provided that in formula I, R5 and R7 are not H or R6 is not H or methoxy; and in formula II that if R4 is carbonyldioxy then R7 is not methoxy.