公开(公告)号：EP3427726A1

公开(公告)日：2019-01-16

申请号：EP17763162.9

申请日：2017-03-06

申请人： Osaka University ,  National Institute for Materials Science ,  Nippon Zoki Pharmaceutical Co., Ltd.

发明人： TANAKA, Hiroyuki ,  OKADA, Kiyoshi ,  YOSHIKAWA, Hideki ,  SUZUKI, Koji ,  EBARA, Mitsuhiro

IPC分类号： A61K9/70 ,  A61K31/714 ,  A61K35/36 ,  A61K38/18 ,  A61K45/00 ,  A61K47/34 ,  A61K47/36 ,  A61P25/00 ,  A61P25/02

摘要： Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.