公开(公告)号：EP1834638A1

公开(公告)日：2007-09-19

申请号：EP05857295.9

申请日：2005-12-02

申请人： Osmotica Corp.

发明人： Meyer, Glenn A. ,  Feleder, Ethel C. ,  Ricci, Marcelo A. ,  Coppari, Marcelo A. ,  Befumo, Marcelo E. ,  Faour, Joaquina ,  Vergez, Juan A.

IPC分类号： A61K31/13 ,  A61K9/20 ,  A61K9/28

CPC分类号： A61K31/13 ,  A61K9/0004 ,  A61K9/2009 ,  A61K9/2866

摘要： The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is modified from a first order release profile to a zero order, pseudo-zero order or sigmoidal release profile by increasing the amount of the osmotic salt in the core of the device. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt.

摘要翻译： 本发明的渗透装置含有包含金刚烷胺和渗透盐的盐的单一核心，其中两种盐具有共同的离子。 金刚烷胺的释放速率通过增加器件芯体中渗透盐的量从一级释放曲线修改为零级，伪零级或S形释放曲线。 渗透装置包括具有受控孔隙率的半透膜，其可以根据需要进行调整，以与渗透盐配合以提供预定的药物释放曲线。 渗透盐不需要涂覆，并且与金刚烷胺盐混合。