公开(公告)号：EP1714641B8

公开(公告)日：2010-05-19

申请号：EP05850136.2

申请日：2005-01-03

申请人： Osmotica Corp.

发明人： FELEDER, Ethel C. ,  MEYER, Glenn A. ,  RICCI, Marcelo A. ,  BEFUMO, Marcelo F. ,  FAOUR, Joaquina ,  PASTINI, Ana C.

IPC分类号： A61K9/32 ,  A61K31/137

CPC分类号： A61K9/0004 ,  A61K31/13 ,  A61K31/137 ,  A61K31/277

公开(公告)号：EP1909768A1

公开(公告)日：2008-04-16

申请号：EP06828467.8

申请日：2006-08-04

申请人： Osmotica Corp.

发明人： BEFUMO, Marcelo ,  RICCI, Marcelo A. ,  FELEDER, Ethel C. ,  MEYER, Glenn A. ,  FAOUR, Joaquina ,  VERGEZ, Juan A.

IPC分类号： A61K9/24 ,  A61K9/32 ,  A61K31/198 ,  A61K9/22

CPC分类号： A61K9/2009 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2866 ,  A61K31/137 ,  A61K31/198 ,  A61K45/06

摘要： The invention provides a compressed tablet that provides a extended release tablet containing a extended release form of carbidopa and a extended release form of levodopa. The tablet optionally further comprises an immediate or rapid release composition of carbidopa and/or levodopa. The extended release composition in the tablet excludes a release rate-controlling polymer, and a release rate-controlling coating; however, the release of the carbidopa and/or levodopa is independently optionally delayed for a lag time. The invention also provides a tablet having a extended release form of levodopa and a rapid or immediate release form of carbidopa. A tablet can contain levodopa present in extended release form and rapid or immediate release form, and carbidopa present in extended release form and rapid or immediate release form. The tablet is used to treat Parkinson's disease and other movement related disorders, diseases or syndromes.