公开(公告)号：EP1303483A1

公开(公告)日：2003-04-23

申请号：EP01958602.3

申请日：2001-08-20

申请人： PACIFIC CORPORATION

发明人： SUH, Young, Ger ,  OH, Uh, Taek ,  KIM, Hee, Doo ,  LEE, Jee, Woo ,  PARK, Hyeung, Geun ,  PARK, Ok, Hui ,  LEE, Yong, Sil ,  PARK, Young, Ho ,  JOO, Yung, Hyup ,  CHOI, Jin, Kyu ,  LIM, K.M. ,  KIM, S.Y. ,  KIM, Jin, Kwan ,  KOH, Hyun, Ju ,  MOH, Joo, Hyun ,  JEONG, Yeon, Su ,  YI, Jung, Bum ,  OH, Young, Im

IPC分类号： C07C335/16 ,  C07C311/00 ,  A61K31/00 ,  C07D221/00

CPC分类号： C07D333/42 ,  C07C311/08 ,  C07C311/47 ,  C07C333/20 ,  C07C335/12 ,  C07C335/14 ,  C07C335/20 ,  C07C335/26 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/323 ,  C07D207/416 ,  C07D207/42 ,  C07D209/08 ,  C07D209/14 ,  C07D213/40 ,  C07D213/61 ,  C07D213/76 ,  C07D217/06 ,  C07D231/14 ,  C07D231/56 ,  C07D233/64 ,  C07D235/14 ,  C07D239/42 ,  C07D241/12 ,  C07D241/24 ,  C07D277/28 ,  C07D295/13 ,  C07D295/215 ,  C07D295/32 ,  C07D307/52 ,  C07D311/58 ,  C07D317/58 ,  C07D333/20

摘要： The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

公开(公告)号：EP1303483B1

公开(公告)日：2008-04-23

申请号：EP01958602.3

申请日：2001-08-20

申请人： PACIFIC CORPORATION

发明人： SUH, Young, Ger ,  OH, Uh, Taek ,  KIM, Hee, Doo ,  LEE, Jee, Woo ,  PARK, Hyeung, Geun ,  PARK, Ok, Hui ,  LEE, Yong, Sil ,  PARK, Young, Ho ,  JOO, Yung, Hyup ,  CHOI, Jin, Kyu ,  LIM, K.M. ,  KIM, S.Y. ,  KIM, Jin, Kwan ,  KOH, Hyun, Ju ,  MOH, Joo, Hyun ,  JEONG, Yeon, Su ,  YI, Jung, Bum ,  OH, Young, Im

IPC分类号： C07C335/16 ,  C07C311/00 ,  A61K31/00 ,  C07D221/00

CPC分类号： C07D333/42 ,  C07C311/08 ,  C07C311/47 ,  C07C333/20 ,  C07C335/12 ,  C07C335/14 ,  C07C335/20 ,  C07C335/26 ,  C07C2601/14 ,  C07C2602/10 ,  C07D207/323 ,  C07D207/416 ,  C07D207/42 ,  C07D209/08 ,  C07D209/14 ,  C07D213/40 ,  C07D213/61 ,  C07D213/76 ,  C07D217/06 ,  C07D231/14 ,  C07D231/56 ,  C07D233/64 ,  C07D235/14 ,  C07D239/42 ,  C07D241/12 ,  C07D241/24 ,  C07D277/28 ,  C07D295/13 ,  C07D295/215 ,  C07D295/32 ,  C07D307/52 ,  C07D311/58 ,  C07D317/58 ,  C07D333/20

摘要： The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.