公开(公告)号：EP1448228A2

公开(公告)日：2004-08-25

申请号：EP02773900.2

申请日：2002-10-24

申请人： PAPPAGALLO, Marco ,  MASTRONARDI, Luciano

发明人： PAPPAGALLO, Marco ,  MASTRONARDI, Luciano

IPC分类号： A61K38/33 ,  A61K9/14 ,  A61K9/50

CPC分类号： A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/485 ,  A61K38/18 ,  A61K45/06 ,  A61K47/36 ,  A61K47/42 ,  A61K2300/00

摘要： A formulation containing an opioid such as morphine in a low dose in a controlled release carrier, such as the carbohydrate polymer gel marketed as ADCON®*-L, can be administered to patients to treat pain over a period of one or more days following surgery of the spinal column or other structures associated with the central nervous system. In one embodiment, the morphine is administered at the end of a lumbar microdicectomy. A low dose can be used as compared to previous studies in which the morphine was administered in solution, typically at levels of about 2-4 mg morphine when administered in a paste, or 10 mg morphine when administered as an epidural solution.