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公开(公告)号：EP0944310A1
公开(公告)日：1999-09-29
申请号：EP97947537.0
申请日：1997-11-17
CPC分类号： A61K8/37 , A61K8/345 , A61K8/39 , A61K8/676 , A61K8/97 , A61K2800/522 , A61Q19/00 , A61Q19/001 , A61Q19/08
摘要： Fatty acid esters of ascorbic acid, particularly saturated fatty acid esters such as ascorbyl palmitate, their salts, ascorbic acid and its salts are solubilized in large amounts, e.g., up to about 25 % by weight, and stabilized using special solvent systems. Useful solvents include polyethylene glycol, ethoxydiglycol, propylene glycol, butylene glycol, propylene carbonate, glycerin, a capric glyceride, a caprylic glyceride, an alkyl lactate, an alkyl adipate, an isosorbide, and mixtures thereof. Preferred dermatological compositions made using these solvents with ascorbic acid and/or at least one of its derivatives also include dimethylaminoethanol, tyrosine, proline, cystine, a penetration enhancer such as oleic acid, urea or mixtures thereof, and at least one natural and/or chemical antioxidant. Natural antioxidants that contain at least about 50 % polyphenols and 50 % catachins such as grape seed or green tea extracts are employed in some embodiments.
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公开(公告)号：EP0944310B1
公开(公告)日：2005-04-06
申请号：EP97947537.3
申请日：1997-11-17
CPC分类号： A61K8/37 , A61K8/345 , A61K8/39 , A61K8/676 , A61K8/97 , A61K2800/522 , A61Q19/00 , A61Q19/001 , A61Q19/08
摘要： Fatty acid esters of ascorbic acid, particularly saturated fatty acid esters such as ascorbyl palmitate, their salts, ascorbic acid and its salts are solubilized in large amounts, e.g., up to about 25 % by weight, and stabilized using special solvent systems. Useful solvents include polyethylene glycol, ethoxydiglycol, propylene glycol, butylene glycol, propylene carbonate, glycerin, a capric glyceride, a caprylic glyceride, an alkyl lactate, an alkyl adipate, an isosorbide, and mixtures thereof. Preferred dermatological compositions made using these solvents with ascorbic acid and/or at least one of its derivatives also include dimethylaminoethanol, tyrosine, proline, cystine, a penetration enhancer such as oleic acid, urea or mixtures thereof, and at least one natural and/or chemical antioxidant. Natural antioxidants that contain at least about 50 % polyphenols and 50 % catachins such as grape seed or green tea extracts are employed in some embodiments.
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公开(公告)号：EP1578325A2
公开(公告)日：2005-09-28
申请号：EP03815011.6
申请日：2003-12-31
IPC分类号： A61F13/00
CPC分类号： A61K9/127 , A61K9/0014
摘要： A stable composition of a drug comprising a carrier having a phosphatidylcholine component which entraps the drug is applied to the skin for transdermal delivery of the drug.
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