专利检索 ap:("PFIZER INC.") AND inv:"WIGHTLIN, Matthew, David" 第 1 页

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发明公开
POLYMORPHIC AND AMORPHOUS FORMS OF 2,5-DIMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID-{2-FLUORO-5-¬3-((E)-2-PYRIDIN-2-YLVINYL)-1H-INDAZOL-6-YLAMINO|-PHENYL}-AMIDE 审中-公开
标题翻译：多晶形物和{2-氟-5- [3 - （（E）-2-吡啶-2-基 - 乙烯基）-1H-吲唑-6-基氨基]苯基}非晶形式-2,5-二甲基-2H-吡唑 -3-羧酸酰胺

公开(公告)号：EP1745035A1

公开(公告)日：2007-01-24

申请号：EP05708711.6

申请日：2005-03-04

申请人： PFIZER INC.

发明人： YE, Qiang, Pfizer Global Research and Development , ZOOK, Scott, Edward , OUELLETTE, Michael, Allen , HETTINGER, Donald, Nicholas , SRIRANGAM, Jayaram K., Pfizer Global Res. & Dev. , KANIA, Robert S., Pfizer Global Research and Dev. , SAEED, Nabil L., Pfizer Global Research and Dev. , WIGHTLIN, Matthew, David , MITCHELL, Mark B., Pfizer Global Research and Dev.

IPC分类号： C07D401/14

CPC分类号： C07D401/14

摘要： The invention provides several polymorphic forms and an amorphous form of 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid {2-fluoro-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6ylamino]-phenyl}-amide, pharmaceutical compositions containing such polymorphic or amorphous forms, and methods of using such pharmaceutical compositions to treat disease states mediated by protein kinases, such as cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation.