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1.发明公开VECTORS AND VECTOR SYSTEMS INCLUDING GENES ENCODING TUMOR SUPPRESSOR PROTEINS AND PRODUCER CELLS TRANSFORMED THEREBY 失效向量和向量系统，包括基因TUMORSUPRESSORPROTEINE代码和生成细胞经变换会。
公开(公告)号：EP0682698A1
公开(公告)日：1995-11-22
申请号：EP95904883.0
申请日：1994-12-09
申请人： PHARMAGENICS, INC.
IPC分类号： C07K14
CPC分类号： C07K14/4746 , C12N2799/027
摘要： Vectors and vector systems are embodied that include a gene encoding a tumor suppressor protein. In one embodiment, the vector includes a gene encoding a tumor suppressor protein and an inducible promoter controlling the gene encoding a tumor suppressor protein. The tumor suppressor protein may be p53 protein. In another embodiment, there is provided a vector system which comprises a first vector including a gene encoding a tumor suppressor protein, and a second vector containing a nucleic acid sequence encoding an antisense sequence complementary to all or a portion of the gene encoding a tumor suppressor protein. In yet another embodiment, there is provided a vector system which comprises a first vector including a gene encoding a tumor suppressor protein, and a second vector containing a gene which encodes a protein which binds to, and thereby inhibits, the tumor suppressor protein. Such vectors and vector systems enable cells transformed thereby to continue to proliferate such that adequate amounts of infectious viral particles, generated from viral vectors including a gene encoding a tumor suppressor protein, can be harvested for administration to patients.
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