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1.发明公开PROCEDE DE PREPARATION D'UN COMPOSE D'INTERACTION DE SUBSTANCES ACTIVES AVEC UN SUPPORT POREUX PAR FLUIDE SUPERCRITIQUE 有权具有多孔支持Active成分的相互作用组合对经历一个关键的关于流体方法
公开(公告)号：EP1434567A1
公开(公告)日：2004-07-07
申请号：EP02796803.1
申请日：2002-10-11
发明人： FREISS, Bernard , MARCIACQ, Florence , FAGES, Jacques , SAUCEAU, Martial , LOCHARD, Hubert , LETOURNEAU, Jean-Jacques , JOUSSOT-DUBIEN, Christophe
CPC分类号： A61K9/1652 , A61K9/1694
摘要： The invention concerns a method for preparing compounds for interaction of an active substance hardly soluble in an aqueous medium with a porous support. The invention is characterized in that it comprises the following steps: (a) mixing the active substance generated by supercritical fluid and the specific amount of porous support; (b) carrying out a molecular diffusion step by contacting in static mode a supercritical fluid with the mixture obtained at step (a) for the time required to improve the dissolution in the aqueous medium of the mixture obtained at step (a); (c) washing the interactive compound obtained at step (b) with a supercritical fluid flow; (d) recuperating the particles of the interactive compound thus formed. The invention also concerns a compound obtainable by said method.
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2.发明授权PROCEDE DE PREPARATION D'UN COMPOSE D'INTERACTION DE SUBSTANCES ACTIVES AVEC UN SUPPORT POREUX PAR FLUIDE SUPERCRITIQUE 有权具有多孔支持Active成分的相互作用组合对经历一个关键的关于流体方法
公开(公告)号：EP1434567B1
公开(公告)日：2007-12-19
申请号：EP02796803.1
申请日：2002-10-11
发明人： FREISS, Bernard , MARCIACQ, Florence , FAGES, Jacques , SAUCEAU, Martial , LOCHARD, Hubert , LETOURNEAU, Jean-Jacques , JOUSSOT-DUBIEN, Christophe
CPC分类号： A61K9/1652 , A61K9/1694
摘要： The invention concerns a method for preparing compounds for interaction of an active substance hardly soluble in an aqueous medium with a porous support. The invention is characterized in that it comprises the following steps: (a) mixing the active substance generated by supercritical fluid and the specific amount of porous support; (b) carrying out a molecular diffusion step by contacting in static mode a supercritical fluid with the mixture obtained at step (a) for the time required to improve the dissolution in the aqueous medium of the mixture obtained at step (a); (c) washing the interactive compound obtained at step (b) with a supercritical fluid flow; (d) recuperating the particles of the interactive compound thus formed. The invention also concerns a compound obtainable by said method.
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