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公开(公告)号：EP2094701A2
公开(公告)日：2009-09-02
申请号：EP07871726.1
申请日：2007-12-20
申请人： PLEXXIKON, INC.
发明人： IBRAHIM, Prabha N. , BREMER, Ryan , ZHANG, Chao , ZHANG, Jiazhong , HIRTH, Klaus-Peter , WU, Guoxian , ZHU, Hongyao
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds according to formulae IIa, IIIa, IIIc and IVb active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号：EP3004060A1
公开(公告)日：2016-04-13
申请号：EP14733877.6
申请日：2014-05-29
申请人： PLEXXIKON INC.
发明人： ZHANG, Chao , HIRTH, Klaus-Peter , IBRAHIM, Prabha N. , NESPI, Marika , SHI, Songyuan , SPEVAK, Wayne , HABETS, Gaston G. , BURTON, Elizabeth, A.
IPC分类号： C07D213/75 , C07D417/04 , C07D471/04 , C07D487/04 , A61K31/519
摘要： Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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3.发明授权
公开(公告)号：EP2395004B1
公开(公告)日：2016-01-20
申请号：EP11173701.1
申请日：2006-06-21
申请人： PLEXXIKON INC.
发明人： IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00 , C07C37/62 , C07C39/27 , C07C47/565 , C07C47/575 , C07D209/08 , C07C45/00 , C07C45/67 , C07C45/71 , C07C49/517
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds (III) active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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4.发明公开
公开(公告)号：EP2395004A3
公开(公告)日：2012-04-04
申请号：EP11173701.1
申请日：2006-06-21
申请人： PLEXXIKON, INC.
发明人： IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00 , C07C37/62 , C07C39/27 , C07C47/565 , C07C47/575 , C07D209/08 , C07C45/00 , C07C45/67 , C07C45/71 , C07C49/517
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds (III) active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号：EP3004060B1
公开(公告)日：2019-11-27
申请号：EP14733877.6
申请日：2014-05-29
申请人： PLEXXIKON INC.
发明人： ZHANG, Chao , HIRTH, Klaus-Peter , IBRAHIM, Prabha N. , NESPI, Marika , SHI, Songyuan , SPEVAK, Wayne , HABETS, Gaston G. , BURTON, Elizabeth, A.
IPC分类号： C07D213/75 , C07D417/04 , C07D471/04 , C07D487/04 , A61K31/519
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公开(公告)号：EP2827904A1
公开(公告)日：2015-01-28
申请号：EP13714152.9
申请日：2013-03-18
申请人： Plexxikon, Inc.
IPC分类号： A61K45/06 , A61K31/436 , A61K31/437 , A61K31/4545 , A61K31/506 , A61P35/00 , A61P19/08 , A61P19/10 , A61P25/28 , A61P25/00 , A61P25/30
CPC分类号： A61K31/444 , A61K9/0053 , A61K31/357 , A61K31/436 , A61K31/437 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K2300/00 , C07D471/04
摘要： The present disclosure provides methods of using protein kinase inhibitors for treating diseases and conditions, including diseases and conditions associated with activity of any protein kinase selected from Fms protein kinase including any mutations thereof, Kit protein kinase any mutations thereof, Flt-3 protein kinase any mutations thereof and combinations thereof.
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7.发明公开
公开(公告)号：EP2395004A2
公开(公告)日：2011-12-14
申请号：EP11173701.1
申请日：2006-06-21
申请人： PLEXXIKON, INC.
发明人： IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00 , C07C37/62 , C07C39/27 , C07C47/565 , C07C47/575 , C07D209/08 , C07C45/00 , C07C45/67 , C07C45/71 , C07C49/517
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds (III) active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译： 描述了对蛋白激酶有活性的化合物（III），以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
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公开(公告)号：EP1893612B1
公开(公告)日：2011-08-03
申请号：EP06773861.7
申请日：2006-06-21
申请人： PLEXXIKON, INC.
发明人： IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , C07C49/517 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds (III) active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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9.发明公开
公开(公告)号：EP1893612A1
公开(公告)日：2008-03-05
申请号：EP06773861.7
申请日：2006-06-21
申请人： PLEXXIKON, INC.
发明人： IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , C07C49/517 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds (III) active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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